Version history

{
  "scope": "mouse primary visual cortex, P28 vs P56, acute slice and in vivo imaging",
  "claim_text": "During the critical period for binocular plasticity in mouse V1, basal-forebrain acetylcholine directly excites SST interneurons, enabling compartmentalized dendritic spiking; this cholinergic responsiveness is lost in adulthood, and suppressing SST cells during the critical period prevents normal development of binocular receptive fields.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-019-0963-3",
    "claim": "During the critical period for binocular plasticity in mouse V1, basal-forebrain acetylcholine directly excites SST interneurons, enabling compartmentalized dendritic spiking; this cholinergic responsiveness is lost in adulthood, and suppressing SST cells during the critical period prevents normal development of binocular receptive fields.",
    "title": null,
    "cite_key": "Yaeger2019",
    "evidence": "Body, Results: in vivo two-photon imaging of L2/3 pyramidal dendrites in V1, slice recordings of SST and VIP interneurons, optogenetic SST suppression at P28 vs P56.",
    "effect_size": "Direct cholinergic response present at P28 but absent at P56 in SST cells",
    "text_access": "fulltext",
    "study_system": "mouse primary visual cortex, P28 vs P56, acute slice and in vivo imaging",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single-study",
    "_source_cluster_index": 7,
    "claim_source_sentence": "Conversely, suppressing SST cell activity during the critical period prevents the normal development of binocular receptive fields by impairing the maturation of ipsilateral eye inputs.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Notably, this direct cholinergic response was not present at P56, despite unchanged intrinsic properties ( Fig. 1e–f , Extended Data Fig. 2 )."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "Direct cholinergic response present at P28 but absent at P56 in SST cells",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-d2aa74034d77"
  ],
  "source_span": "Conversely, suppressing SST cell activity during the critical period prevents the normal development of binocular receptive fields by impairing the maturation of ipsilateral eye inputs.",
  "study_system": "mouse primary visual cortex, P28 vs P56, acute slice and in vivo imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-d2aa74034d77"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Body, Results: in vivo two-photon imaging of L2/3 pyramidal dendrites in V1, slice recordings of SST and VIP interneurons, optogenetic SST suppression at P28 vs P56.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}