Details
- scope
- mouse primary visual cortex, P28 vs P56, acute slice and in vivo imaging
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- effect_size
- Direct cholinergic response present at P28 but absent at P56 in SST cells
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-03-development
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- Conversely, suppressing SST cell activity during the critical period prevents the normal development of binocular receptive fields by impairing the maturation of ipsilateral eye inputs.
- study_system
- mouse primary visual cortex, P28 vs P56, acute slice and in vivo imaging
- section_title
- Developmental Origins and Postnatal Maturation
- evidence_summary
- Body, Results: in vivo two-photon imaging of L2/3 pyramidal dendrites in V1, slice recordings of SST and VIP interneurons, optogenetic SST suppression at P28 vs P56.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- single-study
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-03-development
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
During the critical period for binocular plasticity in mouse V1, basal-forebrain acetylcholine directly excites SST interneurons, enabling compartmentalized dendritic spiking; this cholinergic responsiveness is lost in adulthood, and suppressing SST cells during the critical period prevents normal development of binocular receptive fields.
- raw_fields
{ "n": null, "doi": "10.1038/s41586-019-0963-3", "claim": "During the critical period for binocular plasticity in mouse V1, basal-forebrain acetylcholine directly excites SST interneurons, enabling compartmentalized dendritic spiking; this cholinergic responsiveness is lost in adulthood, and suppressing SST cells during the critical period prevents normal development of binocular receptive fields.", "title": null, "cite_key": "Yaeger2019", "evidence": "Body, Results: in vivo two-photon imaging of L2/3 pyramidal dendrites in V1, slice recordings of SST and VIP interneurons, optogenetic SST suppression at P28 vs P56.", "effect_size": "Direct cholinergic response present at P28 but absent at P56 in SST cells", "text_access": "fulltext", "study_system": "mouse primary visual cortex, P28 vs P56, acute slice and in vivo imaging", "_source_cluster": "cluster_02_development_lineage", "replication_status": "single-study", "_source_cluster_index": 7, "claim_source_sentence": "Conversely, suppressing SST cell activity during the critical period prevents the normal development of binocular receptive fields by impairing the maturation of ipsilateral eye inputs.", "replication_evidence_dois": [], "effect_size_source_sentence": "Notably, this direct cholinergic response was not present at P56, despite unchanged intrinsic properties ( Fig. 1e–f , Extended Data Fig. 2 )." }- source_refs
[ "paper:paper-d2aa74034d77" ]
- evidence_refs
[ { "ref": "paper:paper-d2aa74034d77" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }