Version history

{
  "scope": "mouse cortex (VIP-Cre conditional)",
  "claim_text": "Selective loss of MeCP2 from VIP+ cortical interneurons in mice replicates key neural and behavioral phenotypes of global MeCP2 deficiency, identifying CGE-derived VIP interneurons as a developmental locus of vulnerability in Rett Syndrome.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.55639",
    "claim": "Selective loss of MeCP2 from VIP+ cortical interneurons in mice replicates key neural and behavioral phenotypes of global MeCP2 deficiency, identifying CGE-derived VIP interneurons as a developmental locus of vulnerability in Rett Syndrome.",
    "title": null,
    "cite_key": "Mossner2020",
    "evidence": "Conditional VIP-Cre Mecp2 deletion mouse with electrophysiology and behavioral assays.",
    "effect_size": "qualitative",
    "text_access": "abstract_only",
    "study_system": "mouse cortex (VIP-Cre conditional)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 77,
    "claim_source_sentence": "Here we find that loss of MeCP2 specifically from VIP interneurons replicates key neural and behavioral phenotypes observed following global Mecp2 loss of function.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "qualitative",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-4effa559f79e"
  ],
  "source_span": "Here we find that loss of MeCP2 specifically from VIP interneurons replicates key neural and behavioral phenotypes observed following global Mecp2 loss of function.",
  "study_system": "mouse cortex (VIP-Cre conditional)",
  "evidence_refs": [
    {
      "ref": "paper:paper-4effa559f79e"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Conditional VIP-Cre Mecp2 deletion mouse with electrophysiology and behavioral assays.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}