Selective loss of MeCP2 from VIP+ cortical interneurons in mice replicates key…

Details

scope: mouse cortex (VIP-Cre conditional)
claim_text: Selective loss of MeCP2 from VIP+ cortical interneurons in mice replicates key neural and behavioral phenotypes of global MeCP2 deficiency, identifying CGE-derived VIP interneurons as a developmental locus of vulnerability in Rett Syndrome.
section_id: section_03
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
effect_size: qualitative
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-03-development
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: Here we find that loss of MeCP2 specifically from VIP interneurons replicates key neural and behavioral phenotypes observed following global Mecp2 loss of function.
study_system: mouse cortex (VIP-Cre conditional)
section_title: Developmental Origins and Postnatal Maturation
evidence_summary: Conditional VIP-Cre Mecp2 deletion mouse with electrophysiology and behavioral assays.
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-03-development
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.7554/elife.55639",
  "claim": "Selective loss of MeCP2 from VIP+ cortical interneurons in mice replicates key neural and behavioral phenotypes of global MeCP2 deficiency, identifying CGE-derived VIP interneurons as a developmental locus of vulnerability in Rett Syndrome.",
  "title": null,
  "cite_key": "Mossner2020",
  "evidence": "Conditional VIP-Cre Mecp2 deletion mouse with electrophysiology and behavioral assays.",
  "effect_size": "qualitative",
  "text_access": "abstract_only",
  "study_system": "mouse cortex (VIP-Cre conditional)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 77,
  "claim_source_sentence": "Here we find that loss of MeCP2 specifically from VIP interneurons replicates key neural and behavioral phenotypes observed following global Mecp2 loss of function.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-4effa559f79e"
]

evidence_refs

[
  {
    "ref": "paper:paper-4effa559f79e"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
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  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

Selective loss of MeCP2 from VIP+ cortical interneurons in mice replicates key…

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