Version history

{
  "scope": "adult mouse V1, MICrONS EM connectomics + two-photon functional imaging of L2/3 excitatory neurons",
  "claim_text": "MICrONS analysis of mouse V1 reveals a translaminar hierarchy among L2/3 excitatory neurons: postsynaptic neurons display greater invariance than their presynaptic inputs, and lower-invariance neurons form more local connections — linking synaptic connectivity to a within-layer hierarchy of visual computation.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41593-026-02213-3",
    "claim": "MICrONS analysis of mouse V1 reveals a translaminar hierarchy among L2/3 excitatory neurons: postsynaptic neurons display greater invariance than their presynaptic inputs, and lower-invariance neurons form more local connections — linking synaptic connectivity to a within-layer hierarchy of visual computation.",
    "cite_key": "Ding2026a",
    "evidence": "Inception-loop paradigm in mouse V1 combining large-scale two-photon recordings, predictive deep-network models and in silico/in vivo verification; intersected with MICrONS EM connectomic graph in L2/3 to test invariance hierarchy.",
    "effect_size": "Postsynaptic > presynaptic invariance in L2/3 (direction reported, magnitudes in figures); lower-invariance neurons formed more synaptic connections.",
    "text_access": "fulltext",
    "study_system": "adult mouse V1, MICrONS EM connectomics + two-photon functional imaging of L2/3 excitatory neurons",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Analysis of the MICrONS dataset revealed a hierarchy of excitatory neurons in mouse V1 layers 2/3: postsynaptic neurons exhibited greater invariance than their presynaptic inputs, while neurons with lower invariance formed more connections.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1101/2023.03.15.532836"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Postsynaptic > presynaptic invariance in L2/3 (direction reported, magnitudes in figures); lower-invariance neurons formed more synaptic connections.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
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  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-3d840e4fd22c"
  ],
  "source_span": "Analysis of the MICrONS dataset revealed a hierarchy of excitatory neurons in mouse V1 layers 2/3: postsynaptic neurons exhibited greater invariance than their presynaptic inputs, while neurons with lower invariance formed more connections.",
  "study_system": "adult mouse V1, MICrONS EM connectomics + two-photon functional imaging of L2/3 excitatory neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-3d840e4fd22c"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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  "evidence_summary": "Inception-loop paradigm in mouse V1 combining large-scale two-photon recordings, predictive deep-network models and in silico/in vivo verification; intersected with MICrONS EM connectomic graph in L2/3 to test invariance hierarchy.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}