MICrONS analysis of mouse V1 reveals a translaminar hierarchy among L2/3 excita…

MICrONS analysis of mouse V1 reveals a translaminar hierarchy among L2/3 excitatory neurons: postsynaptic neurons display greater invariance than their presynaptic inputs, and lower-invariance neurons form more local connections — linking synaptic connectivity to a within-layer hierarchy of visual computation.

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  "doi": "10.1038/s41593-026-02213-3",
  "claim": "MICrONS analysis of mouse V1 reveals a translaminar hierarchy among L2/3 excitatory neurons: postsynaptic neurons display greater invariance than their presynaptic inputs, and lower-invariance neurons form more local connections — linking synaptic connectivity to a within-layer hierarchy of visual computation.",
  "cite_key": "Ding2026a",
  "evidence": "Inception-loop paradigm in mouse V1 combining large-scale two-photon recordings, predictive deep-network models and in silico/in vivo verification; intersected with MICrONS EM connectomic graph in L2/3 to test invariance hierarchy.",
  "effect_size": "Postsynaptic > presynaptic invariance in L2/3 (direction reported, magnitudes in figures); lower-invariance neurons formed more synaptic connections.",
  "text_access": "fulltext",
  "study_system": "adult mouse V1, MICrONS EM connectomics + two-photon functional imaging of L2/3 excitatory neurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Analysis of the MICrONS dataset revealed a hierarchy of excitatory neurons in mouse V1 layers 2/3: postsynaptic neurons exhibited greater invariance than their presynaptic inputs, while neurons with lower invariance formed more connections.",
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  "replication_evidence_dois": [
    "10.1101/2023.03.15.532836"
  ],
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