Details
- scope
- mouse cortex, 5xFAD Alzheimer's model
- claim_text
- Biophysical modulation of Kv3 channels, but not changes in their mRNA or protein expression, dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, resulting in gamma-frequency-specific network hyperexcitability.
- section_id
- section_05_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
- effect_size
- gamma-frequency-specific network hyperexcitability from Kv3 biophysical modulation without expression changes
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-05
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- We found that biophysical modulation of Kv3 channels, but not changes in their mRNA or protein expression, were responsible for dampened excitability in young 5xFAD mice.
- study_system
- mouse cortex, 5xFAD Alzheimer's model
- section_title
- Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants
- evidence_summary
- Biophysical ion channel alterations alone reshape cortical network activity prior to changes in expression levels, suggesting Kv3 channel modulation as a novel therapeutic target in early AD.
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-05
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.7554/elife.75316", "claim": "Biophysical modulation of Kv3 channels, but not changes in their mRNA or protein expression, dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, resulting in gamma-frequency-specific network hyperexcitability.", "evidence": "Biophysical ion channel alterations alone reshape cortical network activity prior to changes in expression levels, suggesting Kv3 channel modulation as a novel therapeutic target in early AD.", "effect_size": "gamma-frequency-specific network hyperexcitability from Kv3 biophysical modulation without expression changes", "text_access": "fulltext", "study_system": "mouse cortex, 5xFAD Alzheimer's model", "replication_status": "replication_unknown", "claim_source_sentence": "We found that biophysical modulation of Kv3 channels, but not changes in their mRNA or protein expression, were responsible for dampened excitability in young 5xFAD mice.", "replication_evidence_dois": [], "effect_size_source_sentence": "These K+ conductances could efficiently regulate near-threshold AP firing, resulting in gamma-frequency-specific network hyperexcitability." }- source_refs
[ "paper:paper-9faa92469da0" ]
- evidence_refs
[ { "ref": "paper:paper-9faa92469da0" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }