Version history

{
  "scope": "mouse cortex, 5xFAD Alzheimer's model",
  "claim_text": "Biophysical modulation of Kv3 channels, but not changes in their mRNA or protein expression, dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, resulting in gamma-frequency-specific network hyperexcitability.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.75316",
    "claim": "Biophysical modulation of Kv3 channels, but not changes in their mRNA or protein expression, dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, resulting in gamma-frequency-specific network hyperexcitability.",
    "evidence": "Biophysical ion channel alterations alone reshape cortical network activity prior to changes in expression levels, suggesting Kv3 channel modulation as a novel therapeutic target in early AD.",
    "effect_size": "gamma-frequency-specific network hyperexcitability from Kv3 biophysical modulation without expression changes",
    "text_access": "fulltext",
    "study_system": "mouse cortex, 5xFAD Alzheimer's model",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We found that biophysical modulation of Kv3 channels, but not changes in their mRNA or protein expression, were responsible for dampened excitability in young 5xFAD mice.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "These K+ conductances could efficiently regulate near-threshold AP firing, resulting in gamma-frequency-specific network hyperexcitability."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "gamma-frequency-specific network hyperexcitability from Kv3 biophysical modulation without expression changes",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-9faa92469da0"
  ],
  "source_span": "We found that biophysical modulation of Kv3 channels, but not changes in their mRNA or protein expression, were responsible for dampened excitability in young 5xFAD mice.",
  "study_system": "mouse cortex, 5xFAD Alzheimer's model",
  "evidence_refs": [
    {
      "ref": "paper:paper-9faa92469da0"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Biophysical ion channel alterations alone reshape cortical network activity prior to changes in expression levels, suggesting Kv3 channel modulation as a novel therapeutic target in early AD.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}