Version history

{
  "scope": "mouse Scn1a+/- Dravet syndrome model",
  "claim_text": "Selective pharmacological activation of Nav1.1 with the spider venom peptide Hm1a restores inhibitory neuron function and significantly reduces seizures and mortality in Scn1a+/- Dravet syndrome mice, demonstrating Nav1.1 as a therapeutic target.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1073/pnas.1804764115",
    "claim": "Selective pharmacological activation of Nav1.1 with the spider venom peptide Hm1a restores inhibitory neuron function and significantly reduces seizures and mortality in Scn1a+/- Dravet syndrome mice, demonstrating Nav1.1 as a therapeutic target.",
    "evidence": "Hm1a showed >1000-fold selectivity for hNav1.1 over other Nav1.x members. Mechanism involves slowing of channel inactivation. Proof-of-concept for targeted therapy in genetic epilepsy.",
    "effect_size": ">1000-fold selectivity for Nav1.1; significant reduction in seizures and mortality",
    "text_access": "fulltext",
    "study_system": "mouse Scn1a+/- Dravet syndrome model",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Utilizing a mouse model of Dravet syndrome, Hm1a restored inhibitory neuron function and significantly reduced seizures and mortality in heterozygote mice.",
    "replication_evidence_dois": [
      "10.1016/j.molpha.2025.100072"
    ],
    "effect_size_source_sentence": "Hm1a restored inhibitory neuron function and significantly reduced seizures and mortality in heterozygote mice."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": ">1000-fold selectivity for Nav1.1; significant reduction in seizures and mortality",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-4bb49760633b"
  ],
  "source_span": "Utilizing a mouse model of Dravet syndrome, Hm1a restored inhibitory neuron function and significantly reduced seizures and mortality in heterozygote mice.",
  "study_system": "mouse Scn1a+/- Dravet syndrome model",
  "evidence_refs": [
    {
      "ref": "paper:paper-4bb49760633b"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Hm1a showed >1000-fold selectivity for hNav1.1 over other Nav1.x members. Mechanism involves slowing of channel inactivation. Proof-of-concept for targeted therapy in genetic epilepsy.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}