- claim_text
Selective pharmacological activation of Nav1.1 with the spider venom peptide Hm1a restores inhibitory neuron function and significantly reduces seizures and mortality in Scn1a+/- Dravet syndrome mice, demonstrating Nav1.1 as a therapeutic target.
- raw_fields
{
"n": 0,
"doi": "10.1073/pnas.1804764115",
"claim": "Selective pharmacological activation of Nav1.1 with the spider venom peptide Hm1a restores inhibitory neuron function and significantly reduces seizures and mortality in Scn1a+/- Dravet syndrome mice, demonstrating Nav1.1 as a therapeutic target.",
"evidence": "Hm1a showed >1000-fold selectivity for hNav1.1 over other Nav1.x members. Mechanism involves slowing of channel inactivation. Proof-of-concept for targeted therapy in genetic epilepsy.",
"effect_size": ">1000-fold selectivity for Nav1.1; significant reduction in seizures and mortality",
"text_access": "fulltext",
"study_system": "mouse Scn1a+/- Dravet syndrome model",
"replication_status": "independently_replicated",
"claim_source_sentence": "Utilizing a mouse model of Dravet syndrome, Hm1a restored inhibitory neuron function and significantly reduced seizures and mortality in heterozygote mice.",
"replication_evidence_dois": [
"10.1016/j.molpha.2025.100072"
],
"effect_size_source_sentence": "Hm1a restored inhibitory neuron function and significantly reduced seizures and mortality in heterozygote mice."
}- source_refs
[
"paper:paper-4bb49760633b"
]
- evidence_refs
[
{
"ref": "paper:paper-4bb49760633b"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}