Version history

{
  "scope": "mouse ALM L5B PT, VM thalamus, M1 PT, ALM/M1-projecting TC neurons",
  "claim_text": "Mouse anterolateral motor cortex (ALM) and ventromedial (VM) thalamus form a cell-type-specific excitatory thalamo-cortico-thalamic loop: VM TC axons preferentially excite layer-1 apical-tuft dendrites of VM-projecting L5B PT neurons in ALM (with HCN-mediated gain control), and ALM PT axons reciprocally excite ALM-projecting VM neurons located medially, segregated from M1-related VM circuits.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.1333-18.2018",
    "claim": "Mouse anterolateral motor cortex (ALM) and ventromedial (VM) thalamus form a cell-type-specific excitatory thalamo-cortico-thalamic loop: VM TC axons preferentially excite layer-1 apical-tuft dendrites of VM-projecting L5B PT neurons in ALM (with HCN-mediated gain control), and ALM PT axons reciprocally excite ALM-projecting VM neurons located medially, segregated from M1-related VM circuits.",
    "cite_key": "Guo2018",
    "evidence": "Channelrhodopsin-assisted circuit mapping with retrograde labelling and slice electrophysiology in mouse ALM, M1, and VM thalamus.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse ALM L5B PT, VM thalamus, M1 PT, ALM/M1-projecting TC neurons",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM... The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1... In thalamus, axons from ALM PT neurons excited ALM-projecting VM neurons, located medially in VM... Conversely, M1 PT axons excited M1- but not ALM-projecting VM neurons.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:e0b74a67-34de-4660-b780-ff95451e6841"
  ],
  "source_span": "In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM... The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1... In thalamus, axons from ALM PT neurons excited ALM-projecting VM neurons, located medially in VM... Conversely, M1 PT axons excited M1- but not ALM-projecting VM neurons.",
  "study_system": "mouse ALM L5B PT, VM thalamus, M1 PT, ALM/M1-projecting TC neurons",
  "evidence_refs": [
    {
      "ref": "paper:e0b74a67-34de-4660-b780-ff95451e6841"
    }
  ],
  "section_title": "2. Mouse-cortex anatomy primer — areal map, layer structure, projection-class nomenclature (IT / PT / CT), tools available for E→E dissection (paired patch, Cre lines, two-photon-targeted patch, optogenetics, EM reconstruction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Channelrhodopsin-assisted circuit mapping with retrograde labelling and slice electrophysiology in mouse ALM, M1, and VM thalamus.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}