Mouse anterolateral motor cortex (ALM) and ventromedial (VM) thalamus form a ce…

Mouse anterolateral motor cortex (ALM) and ventromedial (VM) thalamus form a cell-type-specific excitatory thalamo-cortico-thalamic loop: VM TC axons preferentially excite layer-1 apical-tuft dendrites of VM-projecting L5B PT neurons in ALM (with HCN-mediated gain control), and ALM PT axons reciprocally excite ALM-projecting VM neurons located medially, segregated from M1-related VM circuits.

{
  "n": null,
  "doi": "10.1523/jneurosci.1333-18.2018",
  "claim": "Mouse anterolateral motor cortex (ALM) and ventromedial (VM) thalamus form a cell-type-specific excitatory thalamo-cortico-thalamic loop: VM TC axons preferentially excite layer-1 apical-tuft dendrites of VM-projecting L5B PT neurons in ALM (with HCN-mediated gain control), and ALM PT axons reciprocally excite ALM-projecting VM neurons located medially, segregated from M1-related VM circuits.",
  "cite_key": "Guo2018",
  "evidence": "Channelrhodopsin-assisted circuit mapping with retrograde labelling and slice electrophysiology in mouse ALM, M1, and VM thalamus.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse ALM L5B PT, VM thalamus, M1 PT, ALM/M1-projecting TC neurons",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM... The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1... In thalamus, axons from ALM PT neurons excited ALM-projecting VM neurons, located medially in VM... Conversely, M1 PT axons excited M1- but not ALM-projecting VM neurons.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:e0b74a67-34de-4660-b780-ff95451e6841"
]

In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM... The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1... In thalamus, axons from ALM PT neurons excited ALM-projecting VM neurons, located medially in VM... Conversely, M1 PT axons excited M1- but not ALM-projecting VM neurons.

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  }
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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
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