Version history

{
  "scope": "mouse ACx/PFC/mPFC",
  "claim_text": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively 3 , 6 , 16 , 17 .",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature12676",
    "year": "2013",
    "claim": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively 3 , 6 , 16 , 17 .",
    "title": null,
    "journal": "Nature",
    "cite_key": "Pi2013",
    "evidence": "Cortical interneurons that specialize in disinhibitory control",
    "effect_size": "~10%",
    "text_access": "fulltext",
    "first_author": "Pi",
    "study_system": "mouse ACx/PFC/mPFC",
    "_source_cluster": "cluster_06_disinhibition_circuit",
    "author_list_short": "Pi, Hangya, Kvitsiani",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 1,
    "claim_source_sentence": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively 3 , 6 , 16 , 17 .",
    "replication_evidence_dois": [
      "10.1038/nn.3446",
      "10.1038/nn.3544",
      "10.1016/j.cell.2014.01.050"
    ],
    "effect_size_source_sentence": "Indeed, VIP expression demarcates a small population of all interneurons (~10%), distinct from the two major interneuron populations defined by parvalbumin (Pv) and somatostatin (Som) expression 19 , 20 ."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_07_evidence_package.json",
  "effect_size": "~10%",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-07-disinhibition-framework",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-065a0eae69a5"
  ],
  "source_span": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively 3 , 6 , 16 , 17 .",
  "study_system": "mouse ACx/PFC/mPFC",
  "evidence_refs": [
    {
      "ref": "paper:paper-065a0eae69a5"
    }
  ],
  "section_title": "Local Circuit Motifs and the Disinhibition Framework",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Cortical interneurons that specialize in disinhibitory control",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-07-disinhibition-framework",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_07_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}