Details
- scope
- mouse ACx/PFC/mPFC
- section_id
- section_07
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_07_evidence_package.json
- effect_size
- ~10%
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-07-disinhibition-framework
- source_kind
- review_finding
- source_path
- evidence/section_07_evidence_package.json
- study_system
- mouse ACx/PFC/mPFC
- section_title
- Local Circuit Motifs and the Disinhibition Framework
- evidence_summary
- Cortical interneurons that specialize in disinhibitory control
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-07-disinhibition-framework
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_07_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (6)
- claim_text
We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively 3 , 6 , 16 , 17 .
- raw_fields
{ "n": null, "doi": "10.1038/nature12676", "year": "2013", "claim": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively 3 , 6 , 16 , 17 .", "title": null, "journal": "Nature", "cite_key": "Pi2013", "evidence": "Cortical interneurons that specialize in disinhibitory control", "effect_size": "~10%", "text_access": "fulltext", "first_author": "Pi", "study_system": "mouse ACx/PFC/mPFC", "_source_cluster": "cluster_06_disinhibition_circuit", "author_list_short": "Pi, Hangya, Kvitsiani", "replication_status": "independently_replicated", "_source_cluster_index": 1, "claim_source_sentence": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively 3 , 6 , 16 , 17 .", "replication_evidence_dois": [ "10.1038/nn.3446", "10.1038/nn.3544", "10.1016/j.cell.2014.01.050" ], "effect_size_source_sentence": "Indeed, VIP expression demarcates a small population of all interneurons (~10%), distinct from the two major interneuron populations defined by parvalbumin (Pv) and somatostatin (Som) expression 19 , 20 ." }- source_refs
[ "paper:paper-065a0eae69a5" ]
- source_span
We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively 3 , 6 , 16 , 17 .
- evidence_refs
[ { "ref": "paper:paper-065a0eae69a5" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }