Version history

{
  "scope": "vip-interneurons",
  "claim_text": "During active wakefulness in mouse cortex, neocortical layer-1 interneurons (including VIP-class) and SST interneurons across layers are differentially recruited via cholinergic and other neuromodulatory inputs to dynamically shape dendritic inhibition of pyramidal cells.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/science.aag2599",
    "year": "2017",
    "claim": "During active wakefulness in mouse cortex, neocortical layer-1 interneurons (including VIP-class) and SST interneurons across layers are differentially recruited via cholinergic and other neuromodulatory inputs to dynamically shape dendritic inhibition of pyramidal cells.",
    "title": "Layer-specific modulation of neocortical dendritic inhibition during active wakefulness",
    "journal": "",
    "species": "mouse",
    "cite_key": "Munoz2017",
    "evidence": "Channelrhodopsin-assisted patching of SOM and other interneurons across layers in awake behaving mice.",
    "effect_size": "Layer-1 interneurons (VIP/CGE-derived) became active during active wakefulness, while deep SST cells were inhibited — opposite to what superficial-only recordings had implied.",
    "text_access": "abstract_only",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "single_study",
    "_source_cluster_index": 10,
    "claim_source_sentence": "Layer-specific interneuron activity Somatostatin-expressing interneurons are an important group of inhibitory neurons in the brain that target and thus control the dendrites of pyramidal cells.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Muñoz et al. used channelrhodopsin-assisted patching to investigate the spatiotemporal pattern of neocortical dendritic inhibition in vivo. They were able to record the activity of somatostatin-expressing interneurons in all neocortical layers in behaving mice."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "effect_size": "Layer-1 interneurons (VIP/CGE-derived) became active during active wakefulness, while deep SST cells were inhibited — opposite to what superficial-only recordings had implied.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-3f5bd9932217"
  ],
  "source_span": "Layer-specific interneuron activity Somatostatin-expressing interneurons are an important group of inhibitory neurons in the brain that target and thus control the dendrites of pyramidal cells.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-3f5bd9932217"
    }
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Channelrhodopsin-assisted patching of SOM and other interneurons across layers in awake behaving mice.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}