Details
- scope
- vip-interneurons
- section_id
- section_08
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json
- effect_size
- Layer-1 interneurons (VIP/CGE-derived) became active during active wakefulness, while deep SST cells were inhibited — opposite to what superficial-only recordings had implied.
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-08-in-vivo-behavior
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- Layer-specific interneuron activity Somatostatin-expressing interneurons are an important group of inhibitory neurons in the brain that target and thus control the dendrites of pyramidal cells.
- section_title
- In Vivo Function During Behavior
- evidence_summary
- Channelrhodopsin-assisted patching of SOM and other interneurons across layers in awake behaving mice.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- single_study
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-08-in-vivo-behavior
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
During active wakefulness in mouse cortex, neocortical layer-1 interneurons (including VIP-class) and SST interneurons across layers are differentially recruited via cholinergic and other neuromodulatory inputs to dynamically shape dendritic inhibition of pyramidal cells.
- raw_fields
{ "n": null, "doi": "10.1126/science.aag2599", "year": "2017", "claim": "During active wakefulness in mouse cortex, neocortical layer-1 interneurons (including VIP-class) and SST interneurons across layers are differentially recruited via cholinergic and other neuromodulatory inputs to dynamically shape dendritic inhibition of pyramidal cells.", "title": "Layer-specific modulation of neocortical dendritic inhibition during active wakefulness", "journal": "", "species": "mouse", "cite_key": "Munoz2017", "evidence": "Channelrhodopsin-assisted patching of SOM and other interneurons across layers in awake behaving mice.", "effect_size": "Layer-1 interneurons (VIP/CGE-derived) became active during active wakefulness, while deep SST cells were inhibited — opposite to what superficial-only recordings had implied.", "text_access": "abstract_only", "_source_cluster": "cluster_13_neuromodulation", "replication_status": "single_study", "_source_cluster_index": 10, "claim_source_sentence": "Layer-specific interneuron activity Somatostatin-expressing interneurons are an important group of inhibitory neurons in the brain that target and thus control the dendrites of pyramidal cells.", "replication_evidence_dois": [], "effect_size_source_sentence": "Muñoz et al. used channelrhodopsin-assisted patching to investigate the spatiotemporal pattern of neocortical dendritic inhibition in vivo. They were able to record the activity of somatostatin-expressing interneurons in all neocortical layers in behaving mice." }- source_refs
[ "paper:paper-3f5bd9932217" ]
- evidence_refs
[ { "ref": "paper:paper-3f5bd9932217" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }