Version history

{
  "scope": "mouse whole brain (qBrain)",
  "claim_text": "Brain-wide qBrain quantitative cell-type mapping reveals stereotyped, sex-dimorphic distributions of PV+, SST+ and VIP+ interneurons; long-range feedforward cortical inputs preferentially target PV+ cells while feedback inputs preferentially target VIP+ cells, supporting cell-type-specific circuit modules.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.cell.2017.09.020",
    "claim": "Brain-wide qBrain quantitative cell-type mapping reveals stereotyped, sex-dimorphic distributions of PV+, SST+ and VIP+ interneurons; long-range feedforward cortical inputs preferentially target PV+ cells while feedback inputs preferentially target VIP+ cells, supporting cell-type-specific circuit modules.",
    "title": null,
    "cite_key": "Kim2017",
    "evidence": "Whole-brain serial two-photon tomography of Cre-driver/H2B-GFP intersectional reporters; sex-specific quantitative comparisons.",
    "effect_size": ">95% Cre/marker colocalization in adult isocortex; sex-dimorphic SST+/VIP+ cell numbers in 9 brain areas.",
    "text_access": "fulltext",
    "study_system": "mouse whole brain (qBrain)",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "single-study",
    "_source_cluster_index": 18,
    "claim_source_sentence": "Long-range feedforward inputs strongly target PV+ neurons, while long-range feedback inputs tend to target VIP+ neurons, which in turn inhibit SST+ neurons ( ; ; ).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This does not seem to be the case in the adult isocortex, where the Cre-driven labeling of the PV+, SST+, and VIP+ cells colocalizes in >95% cells with the expression of the respective reporter proteins ( ; ; )."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": ">95% Cre/marker colocalization in adult isocortex; sex-dimorphic SST+/VIP+ cell numbers in 9 brain areas.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-fd3c7b95b8f7"
  ],
  "source_span": "Long-range feedforward inputs strongly target PV+ neurons, while long-range feedback inputs tend to target VIP+ neurons, which in turn inhibit SST+ neurons ( ; ; ).",
  "study_system": "mouse whole brain (qBrain)",
  "evidence_refs": [
    {
      "ref": "paper:paper-fd3c7b95b8f7"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Whole-brain serial two-photon tomography of Cre-driver/H2B-GFP intersectional reporters; sex-specific quantitative comparisons.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}