Repetitive two-photon optogenetic co-activation in awake mouse V1 imprints recu…

Repetitive two-photon optogenetic co-activation in awake mouse V1 imprints recurrent neuronal ensembles that recur spontaneously, can be recalled by single-cell stimulation, and persist across days, demonstrating Hebbian-like reconfiguration of cortical excitatory networks.

{
  "n": 0,
  "doi": "10.1126/science.aaf7560",
  "claim": "Repetitive two-photon optogenetic co-activation in awake mouse V1 imprints recurrent neuronal ensembles that recur spontaneously, can be recalled by single-cell stimulation, and persist across days, demonstrating Hebbian-like reconfiguration of cortical excitatory networks.",
  "cite_key": "CarrilloReid2016",
  "evidence": "Two-photon optogenetic patterned co-activation of small V1 populations in awake mice, followed by spontaneous/evoked imaging across consecutive days.",
  "effect_size": "Imprinted ensembles persist across days; single-cell stimulation recalls full ensemble (pattern completion)",
  "text_access": "abstract_only",
  "study_system": "awake mouse V1; two-photon optogenetic ensemble imprinting with chronic Ca imaging",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Here we report that repetitive activation with two-photon optogenetics of neuronal populations from ensembles in the visual cortex of awake mice builds neuronal ensembles that recur spontaneously after being imprinted and do not disrupt preexisting ones.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Moreover, imprinted ensembles can be recalled by single- cell stimulation and remain coactive on consecutive days."
}

[
  "paper:paper-c02ea00d7195"
]

Here we report that repetitive activation with two-photon optogenetics of neuronal populations from ensembles in the visual cortex of awake mice builds neuronal ensembles that recur spontaneously after being imprinted and do not disrupt preexisting ones.

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