Version history

{
  "scope": "mouse S1 forelimb; optogenetic CRACM, retrograde labelling",
  "claim_text": "In mouse hand/forelimb somatosensory cortex, optogenetic stimulation of VPL thalamic axons reveals VPL input to L4 putative excitatory neurons and to identified L2/3 corticocortical, L5A corticocortical, and L5B corticospinal projection neurons, mapping a sensorimotor loop from cuneate→VPL→S1 onto class-specific translaminar excitatory targets.",
  "raw_fields": {
    "n": "mouse forelimb S1 slices; n in figures",
    "doi": "10.7554/elife.66836",
    "claim": "In mouse hand/forelimb somatosensory cortex, optogenetic stimulation of VPL thalamic axons reveals VPL input to L4 putative excitatory neurons and to identified L2/3 corticocortical, L5A corticocortical, and L5B corticospinal projection neurons, mapping a sensorimotor loop from cuneate→VPL→S1 onto class-specific translaminar excitatory targets.",
    "cite_key": "Yamawaki2021",
    "evidence": "Optogenetic stimulation of VPL thalamic axons in mouse S1 forelimb slices combined with retrograde labelling and recordings from L4, L2/3, L5A, and L5B projection neurons.",
    "effect_size": "VPL→L4 stellate inputs strongest; substantial inputs onto L5A IT and L5B corticospinal cells, lesser onto L2/3",
    "text_access": "fulltext",
    "study_system": "mouse S1 forelimb; optogenetic CRACM, retrograde labelling",
    "argument_role": "supporting",
    "replication_status": "consistent with class-specific thalamocortical input to L4/L5B in barrel cortex",
    "claim_source_sentence": "In S1 slices, labeled axons from the VPL neurons were seen in L4, along with retrogradely labeled corticocortical L2/3 and L5A neurons, and corticospinal neurons in L5B. ... We recorded in S1 slices from L4, corticocortical, and corticospinal neurons and sampled excitatory currents evoked by photostimulation of the ChR2-expressing VPL axons.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.7554/eLife.05422",
      "10.1523/JNEUROSCI.4338-12.2013"
    ],
    "effect_size_source_sentence": "Recordings in L4 were targeted to putative excitatory neurons, based on small soma. ... sampled excitatory currents evoked by photostimulation of the ChR2-expressing VPL axons."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "VPL→L4 stellate inputs strongest; substantial inputs onto L5A IT and L5B corticospinal cells, lesser onto L2/3",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-15b98c6c015d"
  ],
  "source_span": "In S1 slices, labeled axons from the VPL neurons were seen in L4, along with retrogradely labeled corticocortical L2/3 and L5A neurons, and corticospinal neurons in L5B. ... We recorded in S1 slices from L4, corticocortical, and corticospinal neurons and sampled excitatory currents evoked by photostimulation of the ChR2-expressing VPL axons.",
  "study_system": "mouse S1 forelimb; optogenetic CRACM, retrograde labelling",
  "evidence_refs": [
    {
      "ref": "paper:paper-15b98c6c015d"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Optogenetic stimulation of VPL thalamic axons in mouse S1 forelimb slices combined with retrograde labelling and recordings from L4, L2/3, L5A, and L5B projection neurons.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent with class-specific thalamocortical input to L4/L5B in barrel cortex",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}