In mouse hand/forelimb somatosensory cortex, optogenetic stimulation of VPL tha…

In mouse hand/forelimb somatosensory cortex, optogenetic stimulation of VPL thalamic axons reveals VPL input to L4 putative excitatory neurons and to identified L2/3 corticocortical, L5A corticocortical, and L5B corticospinal projection neurons, mapping a sensorimotor loop from cuneate→VPL→S1 onto class-specific translaminar excitatory targets.

{
  "n": "mouse forelimb S1 slices; n in figures",
  "doi": "10.7554/elife.66836",
  "claim": "In mouse hand/forelimb somatosensory cortex, optogenetic stimulation of VPL thalamic axons reveals VPL input to L4 putative excitatory neurons and to identified L2/3 corticocortical, L5A corticocortical, and L5B corticospinal projection neurons, mapping a sensorimotor loop from cuneate→VPL→S1 onto class-specific translaminar excitatory targets.",
  "cite_key": "Yamawaki2021",
  "evidence": "Optogenetic stimulation of VPL thalamic axons in mouse S1 forelimb slices combined with retrograde labelling and recordings from L4, L2/3, L5A, and L5B projection neurons.",
  "effect_size": "VPL→L4 stellate inputs strongest; substantial inputs onto L5A IT and L5B corticospinal cells, lesser onto L2/3",
  "text_access": "fulltext",
  "study_system": "mouse S1 forelimb; optogenetic CRACM, retrograde labelling",
  "argument_role": "supporting",
  "replication_status": "consistent with class-specific thalamocortical input to L4/L5B in barrel cortex",
  "claim_source_sentence": "In S1 slices, labeled axons from the VPL neurons were seen in L4, along with retrogradely labeled corticocortical L2/3 and L5A neurons, and corticospinal neurons in L5B. ... We recorded in S1 slices from L4, corticocortical, and corticospinal neurons and sampled excitatory currents evoked by photostimulation of the ChR2-expressing VPL axons.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.7554/eLife.05422",
    "10.1523/JNEUROSCI.4338-12.2013"
  ],
  "effect_size_source_sentence": "Recordings in L4 were targeted to putative excitatory neurons, based on small soma. ... sampled excitatory currents evoked by photostimulation of the ChR2-expressing VPL axons."
}

[
  "paper:paper-15b98c6c015d"
]

In S1 slices, labeled axons from the VPL neurons were seen in L4, along with retrogradely labeled corticocortical L2/3 and L5A neurons, and corticospinal neurons in L5B. ... We recorded in S1 slices from L4, corticocortical, and corticospinal neurons and sampled excitatory currents evoked by photostimulation of the ChR2-expressing VPL axons.

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