Version history

{
  "scope": "mouse mPFC slice with thalamic optogenetics",
  "claim_text": "In mouse PFC, mediodorsal (MD) and ventromedial (VM) thalamic nuclei differentially engage L1 interneurons: VM strongly drives NDNF+ cells in L1a (146 ± 41 pA EPSC vs 6 ± 2 pA at VIP+; ~26× ratio), while MD activates VIP+ cells in L1b approximately equally to NDNF+; VIP+ and NDNF+ cells segregate into L1b vs L1a sublayers and form distinct disinhibitory micro-circuits.",
  "raw_fields": {
    "n": 7,
    "doi": "10.1016/j.neuron.2020.10.031",
    "claim": "In mouse PFC, mediodorsal (MD) and ventromedial (VM) thalamic nuclei differentially engage L1 interneurons: VM strongly drives NDNF+ cells in L1a (146 ± 41 pA EPSC vs 6 ± 2 pA at VIP+; ~26× ratio), while MD activates VIP+ cells in L1b approximately equally to NDNF+; VIP+ and NDNF+ cells segregate into L1b vs L1a sublayers and form distinct disinhibitory micro-circuits.",
    "title": null,
    "cite_key": "Anastasiades2021a",
    "evidence": "Channelrhodopsin photo-stimulation of VM/MD axons + paired whole-cell recordings of VIP+ vs VIP- L1 cells in PFC slices.",
    "effect_size": "VM EPSC ratio VIP-/VIP+ = 25.9 (CI 8.4–82.6, p=0.016); MD ratio = 0.94 (n.s.); higher-order thalamic input fraction VIP+ = 81.7 ± 1.2%, NDNF+ = 79.5 ± 2.2%.",
    "text_access": "fulltext",
    "study_system": "mouse mPFC slice with thalamic optogenetics",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "single-study",
    "_source_cluster_index": 11,
    "claim_source_sentence": "Trains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited robust EPSCs at VIP− cells in L1a, which were much stronger than those at VIP+ cells in L1b (VIP− = −146 ± 41 pA, VIP+ = −6 ± 2 pA, p = 0.016; n = 7 pairs, 5 mice) ( – ).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This differential thalamic targeting of L1 interneurons was highlighted by VIP− / VIP+ input ratios, which were close to unity for MD, but an order of magnitude higher for VM (MD = 0.94, CI = −0.03–3.4, p = 0.58; VM = 25.9, CI = 8.4–82.6, p = 0.016; MD vs."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "VM EPSC ratio VIP-/VIP+ = 25.9 (CI 8.4–82.6, p=0.016); MD ratio = 0.94 (n.s.); higher-order thalamic input fraction VIP+ = 81.7 ± 1.2%, NDNF+ = 79.5 ± 2.2%.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-7227d2a3ed3e"
  ],
  "source_span": "Trains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited robust EPSCs at VIP− cells in L1a, which were much stronger than those at VIP+ cells in L1b (VIP− = −146 ± 41 pA, VIP+ = −6 ± 2 pA, p = 0.016; n = 7 pairs, 5 mice) ( – ).",
  "study_system": "mouse mPFC slice with thalamic optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-7227d2a3ed3e"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Channelrhodopsin photo-stimulation of VM/MD axons + paired whole-cell recordings of VIP+ vs VIP- L1 cells in PFC slices.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}