In mouse PFC, mediodorsal (MD) and ventromedial (VM) thalamic nuclei differenti…

In mouse PFC, mediodorsal (MD) and ventromedial (VM) thalamic nuclei differentially engage L1 interneurons: VM strongly drives NDNF+ cells in L1a (146 ± 41 pA EPSC vs 6 ± 2 pA at VIP+; ~26× ratio), while MD activates VIP+ cells in L1b approximately equally to NDNF+; VIP+ and NDNF+ cells segregate into L1b vs L1a sublayers and form distinct disinhibitory micro-circuits.

{
  "n": 7,
  "doi": "10.1016/j.neuron.2020.10.031",
  "claim": "In mouse PFC, mediodorsal (MD) and ventromedial (VM) thalamic nuclei differentially engage L1 interneurons: VM strongly drives NDNF+ cells in L1a (146 ± 41 pA EPSC vs 6 ± 2 pA at VIP+; ~26× ratio), while MD activates VIP+ cells in L1b approximately equally to NDNF+; VIP+ and NDNF+ cells segregate into L1b vs L1a sublayers and form distinct disinhibitory micro-circuits.",
  "title": null,
  "cite_key": "Anastasiades2021a",
  "evidence": "Channelrhodopsin photo-stimulation of VM/MD axons + paired whole-cell recordings of VIP+ vs VIP- L1 cells in PFC slices.",
  "effect_size": "VM EPSC ratio VIP-/VIP+ = 25.9 (CI 8.4–82.6, p=0.016); MD ratio = 0.94 (n.s.); higher-order thalamic input fraction VIP+ = 81.7 ± 1.2%, NDNF+ = 79.5 ± 2.2%.",
  "text_access": "fulltext",
  "study_system": "mouse mPFC slice with thalamic optogenetics",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "single-study",
  "_source_cluster_index": 11,
  "claim_source_sentence": "Trains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited robust EPSCs at VIP− cells in L1a, which were much stronger than those at VIP+ cells in L1b (VIP− = −146 ± 41 pA, VIP+ = −6 ± 2 pA, p = 0.016; n = 7 pairs, 5 mice) ( – ).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "This differential thalamic targeting of L1 interneurons was highlighted by VIP− / VIP+ input ratios, which were close to unity for MD, but an order of magnitude higher for VM (MD = 0.94, CI = −0.03–3.4, p = 0.58; VM = 25.9, CI = 8.4–82.6, p = 0.016; MD vs."
}

[
  "paper:paper-7227d2a3ed3e"
]

[
  {
    "ref": "paper:paper-7227d2a3ed3e"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}