Version history

{
  "scope": "adult mouse primary motor cortex (M1) layer 5 Fezf2-expressing pyramidal neurons",
  "claim_text": "In mature mouse motor cortex, Fezf2 — previously assumed a strict subcerebral (PT) marker — is expressed in two functionally distinct L5 populations: pyramidal-tract-like Fezf2+ neurons that include corticospinal (CSpPN) and corticothalamic (CThPN) projection cells expressing CTIP2, and intratelencephalic-like Fezf2+ neurons that include crossed-corticostriatal (cCStrPN) and crossed-corticocortical (cCCPN) cells expressing SATB2 — so Fezf2 marks both IT and PT projection classes, with CTIP2/SATB2 disambiguating them.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1002/cne.23875",
    "claim": "In mature mouse motor cortex, Fezf2 — previously assumed a strict subcerebral (PT) marker — is expressed in two functionally distinct L5 populations: pyramidal-tract-like Fezf2+ neurons that include corticospinal (CSpPN) and corticothalamic (CThPN) projection cells expressing CTIP2, and intratelencephalic-like Fezf2+ neurons that include crossed-corticostriatal (cCStrPN) and crossed-corticocortical (cCCPN) cells expressing SATB2 — so Fezf2 marks both IT and PT projection classes, with CTIP2/SATB2 disambiguating them.",
    "cite_key": "Tantirigama2016",
    "evidence": "Fezf2-GFP reporter mouse with whole-cell electrophysiology, morphology reconstruction, cluster analysis, retrograde labeling and CTIP2/SATB2 immunohistochemistry in mouse M1 L5.",
    "effect_size": "qualitative — Fezf2+ subdivides into PT (CTIP2+) and IT (SATB2+) populations in mature M1 L5",
    "text_access": "abstract_only",
    "study_system": "adult mouse primary motor cortex (M1) layer 5 Fezf2-expressing pyramidal neurons",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "we identify a heterogeneous population of Fezf2(+) neurons in both layer 5A and layer 5B of the mature motor cortex. Functional electrophysiology identified two distinct subtypes of Fezf2(+) neurons that resembled pyramidal tract projection neurons (PT-PNs) and intratelencephalic projection neurons (IT-PNs). Retrograde labeling confirmed the former type to include corticospinal projection neurons (CSpPNs) and corticothalamic projection neurons (CThPNs), whereas the latter type included crossed corticostriatal projection neurons (cCStrPNs) and crossed-corticocortical projection neurons (cCCPNs). The two Fezf2(+) subtypes expressed either CTIP2 or SATB2",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.3111-13.2014"
    ],
    "effect_size_source_sentence": "The two Fezf2(+) subtypes expressed either CTIP2 or SATB2"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — Fezf2+ subdivides into PT (CTIP2+) and IT (SATB2+) populations in mature M1 L5",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-89006181f9d5"
  ],
  "source_span": "we identify a heterogeneous population of Fezf2(+) neurons in both layer 5A and layer 5B of the mature motor cortex. Functional electrophysiology identified two distinct subtypes of Fezf2(+) neurons that resembled pyramidal tract projection neurons (PT-PNs) and intratelencephalic projection neurons (IT-PNs). Retrograde labeling confirmed the former type to include corticospinal projection neurons (CSpPNs) and cortic...",
  "study_system": "adult mouse primary motor cortex (M1) layer 5 Fezf2-expressing pyramidal neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-89006181f9d5"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Fezf2-GFP reporter mouse with whole-cell electrophysiology, morphology reconstruction, cluster analysis, retrograde labeling and CTIP2/SATB2 immunohistochemistry in mouse M1 L5.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}