In mature mouse motor cortex, Fezf2 — previously assumed a strict subcerebral (…

In mature mouse motor cortex, Fezf2 — previously assumed a strict subcerebral (PT) marker — is expressed in two functionally distinct L5 populations: pyramidal-tract-like Fezf2+ neurons that include corticospinal (CSpPN) and corticothalamic (CThPN) projection cells expressing CTIP2, and intratelencephalic-like Fezf2+ neurons that include crossed-corticostriatal (cCStrPN) and crossed-corticocortical (cCCPN) cells expressing SATB2 — so Fezf2 marks both IT and PT projection classes, with CTIP2/SATB2 disambiguating them.

{
  "n": 0,
  "doi": "10.1002/cne.23875",
  "claim": "In mature mouse motor cortex, Fezf2 — previously assumed a strict subcerebral (PT) marker — is expressed in two functionally distinct L5 populations: pyramidal-tract-like Fezf2+ neurons that include corticospinal (CSpPN) and corticothalamic (CThPN) projection cells expressing CTIP2, and intratelencephalic-like Fezf2+ neurons that include crossed-corticostriatal (cCStrPN) and crossed-corticocortical (cCCPN) cells expressing SATB2 — so Fezf2 marks both IT and PT projection classes, with CTIP2/SATB2 disambiguating them.",
  "cite_key": "Tantirigama2016",
  "evidence": "Fezf2-GFP reporter mouse with whole-cell electrophysiology, morphology reconstruction, cluster analysis, retrograde labeling and CTIP2/SATB2 immunohistochemistry in mouse M1 L5.",
  "effect_size": "qualitative — Fezf2+ subdivides into PT (CTIP2+) and IT (SATB2+) populations in mature M1 L5",
  "text_access": "abstract_only",
  "study_system": "adult mouse primary motor cortex (M1) layer 5 Fezf2-expressing pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "we identify a heterogeneous population of Fezf2(+) neurons in both layer 5A and layer 5B of the mature motor cortex. Functional electrophysiology identified two distinct subtypes of Fezf2(+) neurons that resembled pyramidal tract projection neurons (PT-PNs) and intratelencephalic projection neurons (IT-PNs). Retrograde labeling confirmed the former type to include corticospinal projection neurons (CSpPNs) and corticothalamic projection neurons (CThPNs), whereas the latter type included crossed corticostriatal projection neurons (cCStrPNs) and crossed-corticocortical projection neurons (cCCPNs). The two Fezf2(+) subtypes expressed either CTIP2 or SATB2",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1523/JNEUROSCI.3111-13.2014"
  ],
  "effect_size_source_sentence": "The two Fezf2(+) subtypes expressed either CTIP2 or SATB2"
}

[
  "paper:paper-89006181f9d5"
]

we identify a heterogeneous population of Fezf2(+) neurons in both layer 5A and layer 5B of the mature motor cortex. Functional electrophysiology identified two distinct subtypes of Fezf2(+) neurons that resembled pyramidal tract projection neurons (PT-PNs) and intratelencephalic projection neurons (IT-PNs). Retrograde labeling confirmed the former type to include corticospinal projection neurons (CSpPNs) and cortic...

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