Details
- scope
- Outpatients with schizophrenia (n=26) and 30 matched healthy individuals
- section_id
- section_14
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- effect_size
- p=.007
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-14
- source_kind
- review_finding
- source_path
- evidence/section_14_evidence_package.json
- source_span
- Conclusions: These findings link two biomarkers of schizophrenia – the sleep spindle density deficit and abnormally increased thalamocortical functional connectivity – and point to deficient TRN inhibition as a plausible mechanism.
- study_system
- Outpatients with schizophrenia (n=26) and 30 matched healthy individuals
- section_title
- Loop Dysfunction in Neurological and Psychiatric Disease
- evidence_summary
- Polysomnography and rs-fMRI in 26 outpatients with schizophrenia and 30 demographically matched controls.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-14
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- claim_text
Schizophrenia is characterized by increased resting-state thalamic functional connectivity with somatosensory and motor cortex and reduced sleep spindle density; the two abnormalities are inversely correlated, consistent with thalamic reticular nucleus disinhibition.
- raw_fields
{ "n": 26, "doi": "10.1016/j.bpsc.2019.04.012", "claim": "Schizophrenia is characterized by increased resting-state thalamic functional connectivity with somatosensory and motor cortex and reduced sleep spindle density; the two abnormalities are inversely correlated, consistent with thalamic reticular nucleus disinhibition.", "cite_key": "Baran2019", "evidence": "Polysomnography and rs-fMRI in 26 outpatients with schizophrenia and 30 demographically matched controls.", "effect_size": "p=.007", "text_access": "fulltext", "study_system": "Outpatients with schizophrenia (n=26) and 30 matched healthy individuals", "source_cluster_id": "cluster_13", "replication_status": "independently_replicated", "claim_source_sentence": "Conclusions: These findings link two biomarkers of schizophrenia – the sleep spindle density deficit and abnormally increased thalamocortical functional connectivity – and point to deficient TRN inhibition as a plausible mechanism.", "replication_evidence_dois": [ "10.1093/schbul/sby166", "10.1016/j.jaac.2020.07.903" ], "effect_size_source_sentence": "Intra-cortical connectivity within the group difference mask was significantly weaker in patients than controls (t(49)=2.8, p=.007; Fig. 3A ) and only controls showed a strong reciprocal relation of intra-cortical connectivity with thalamocortical connectivity (r=−.75, p =2E-6; Patients: r =.19, p =.41; Fig. 3B ), a difference that was significant (β=.84, p =5E-6)." }- source_refs
[ "paper:paper-ddf43a4aa9ab" ]
- evidence_refs
[ { "ref": "paper:paper-ddf43a4aa9ab" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }