Version history

{
  "scope": "Outpatients with schizophrenia (n=26) and 30 matched healthy individuals",
  "claim_text": "Schizophrenia is characterized by increased resting-state thalamic functional connectivity with somatosensory and motor cortex and reduced sleep spindle density; the two abnormalities are inversely correlated, consistent with thalamic reticular nucleus disinhibition.",
  "raw_fields": {
    "n": 26,
    "doi": "10.1016/j.bpsc.2019.04.012",
    "claim": "Schizophrenia is characterized by increased resting-state thalamic functional connectivity with somatosensory and motor cortex and reduced sleep spindle density; the two abnormalities are inversely correlated, consistent with thalamic reticular nucleus disinhibition.",
    "cite_key": "Baran2019",
    "evidence": "Polysomnography and rs-fMRI in 26 outpatients with schizophrenia and 30 demographically matched controls.",
    "effect_size": "p=.007",
    "text_access": "fulltext",
    "study_system": "Outpatients with schizophrenia (n=26) and 30 matched healthy individuals",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Conclusions: These findings link two biomarkers of schizophrenia – the sleep spindle density deficit and abnormally increased thalamocortical functional connectivity – and point to deficient TRN inhibition as a plausible mechanism.",
    "replication_evidence_dois": [
      "10.1093/schbul/sby166",
      "10.1016/j.jaac.2020.07.903"
    ],
    "effect_size_source_sentence": "Intra-cortical connectivity within the group difference mask was significantly weaker in patients than controls (t(49)=2.8, p=.007; Fig. 3A ) and only controls showed a strong reciprocal relation of intra-cortical connectivity with thalamocortical connectivity (r=−.75, p =2E-6; Patients: r =.19, p =.41; Fig. 3B ), a difference that was significant (β=.84, p =5E-6)."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": "p=.007",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-ddf43a4aa9ab"
  ],
  "source_span": "Conclusions: These findings link two biomarkers of schizophrenia – the sleep spindle density deficit and abnormally increased thalamocortical functional connectivity – and point to deficient TRN inhibition as a plausible mechanism.",
  "study_system": "Outpatients with schizophrenia (n=26) and 30 matched healthy individuals",
  "evidence_refs": [
    {
      "ref": "paper:paper-ddf43a4aa9ab"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Polysomnography and rs-fMRI in 26 outpatients with schizophrenia and 30 demographically matched controls.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}