Version history

{
  "scope": "vip-interneurons",
  "claim_text": "Intracortical cholinergic input recruits SST interneurons to drive cortical desynchronization and decorrelation; selective optogenetic SST inhibition (but not VIP inhibition) blocks the desynchronization, identifying SST — not VIP — as the necessary cholinergic node for state change.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nn.4002",
    "year": "2015",
    "claim": "Intracortical cholinergic input recruits SST interneurons to drive cortical desynchronization and decorrelation; selective optogenetic SST inhibition (but not VIP inhibition) blocks the desynchronization, identifying SST — not VIP — as the necessary cholinergic node for state change.",
    "title": "An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity",
    "journal": "",
    "species": "mouse",
    "cite_key": "Chen2015a",
    "evidence": "In vivo Vm recordings + optogenetic silencing of SST and VIP cells during cholinergic axon stimulation in mouse V1.",
    "effect_size": "SST silencing blocked desynchronization; VIP silencing did not.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "conflict_with",
    "_source_cluster_index": 30,
    "claim_source_sentence": "Selective optogenetic inhibition of SOM responses blocks desynchronization and decorrelation, demonstrating that direct cholinergic activation of SOM neurons is necessary for this phenomenon.",
    "replication_evidence_dois": [
      "10.1016/j.cell.2014.01.050",
      "10.1038/nature10674"
    ],
    "effect_size_source_sentence": "Optogenetic inhibition of vasoactive intestinal peptide-expressing neurons does not block desynchronization, despite these neurons being activated at high levels of cholinergic drive."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "SST silencing blocked desynchronization; VIP silencing did not.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-2c3589e2f07a"
  ],
  "source_span": "Selective optogenetic inhibition of SOM responses blocks desynchronization and decorrelation, demonstrating that direct cholinergic activation of SOM neurons is necessary for this phenomenon.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-2c3589e2f07a"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vivo Vm recordings + optogenetic silencing of SST and VIP cells during cholinergic axon stimulation in mouse V1.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "conflict_with",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}