Details
- scope
- vip-interneurons
- section_id
- section_10
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json
- effect_size
- SST silencing blocked desynchronization; VIP silencing did not.
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-10-oscillatory-dynamics
- source_kind
- review_finding
- source_path
- evidence/section_10_evidence_package.json
- source_span
- Selective optogenetic inhibition of SOM responses blocks desynchronization and decorrelation, demonstrating that direct cholinergic activation of SOM neurons is necessary for this phenomenon.
- section_title
- Oscillatory Dynamics and Temporal Coordination
- evidence_summary
- In vivo Vm recordings + optogenetic silencing of SST and VIP cells during cholinergic axon stimulation in mouse V1.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- conflict_with
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-10-oscillatory-dynamics
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Intracortical cholinergic input recruits SST interneurons to drive cortical desynchronization and decorrelation; selective optogenetic SST inhibition (but not VIP inhibition) blocks the desynchronization, identifying SST — not VIP — as the necessary cholinergic node for state change.
- raw_fields
{ "n": null, "doi": "10.1038/nn.4002", "year": "2015", "claim": "Intracortical cholinergic input recruits SST interneurons to drive cortical desynchronization and decorrelation; selective optogenetic SST inhibition (but not VIP inhibition) blocks the desynchronization, identifying SST — not VIP — as the necessary cholinergic node for state change.", "title": "An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity", "journal": "", "species": "mouse", "cite_key": "Chen2015a", "evidence": "In vivo Vm recordings + optogenetic silencing of SST and VIP cells during cholinergic axon stimulation in mouse V1.", "effect_size": "SST silencing blocked desynchronization; VIP silencing did not.", "text_access": "fulltext", "_source_cluster": "cluster_13_neuromodulation", "replication_status": "conflict_with", "_source_cluster_index": 30, "claim_source_sentence": "Selective optogenetic inhibition of SOM responses blocks desynchronization and decorrelation, demonstrating that direct cholinergic activation of SOM neurons is necessary for this phenomenon.", "replication_evidence_dois": [ "10.1016/j.cell.2014.01.050", "10.1038/nature10674" ], "effect_size_source_sentence": "Optogenetic inhibition of vasoactive intestinal peptide-expressing neurons does not block desynchronization, despite these neurons being activated at high levels of cholinergic drive." }- source_refs
[ "paper:paper-2c3589e2f07a" ]
- evidence_refs
[ { "ref": "paper:paper-2c3589e2f07a" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }