Thalamocortical input to mouse barrel cortex evokes action potentials in ~60% o…

Thalamocortical input to mouse barrel cortex evokes action potentials in ~60% of inhibitory interneurons but in <5% of excitatory neurons, with the firing inhibitory interneurons receiving roughly fivefold larger thalamocortical EPSCs — establishing inhibitory cells as the dominant disynaptic feedforward inhibitor.

{
  "n": 0,
  "doi": "10.1523/jneurosci.21-08-02699.2001",
  "claim": "Thalamocortical input to mouse barrel cortex evokes action potentials in ~60% of inhibitory interneurons but in <5% of excitatory neurons, with the firing inhibitory interneurons receiving roughly fivefold larger thalamocortical EPSCs — establishing inhibitory cells as the dominant disynaptic feedforward inhibitor.",
  "cite_key": "Porter2001",
  "evidence": "Cell-attached and whole-cell recordings in layer-IV/V mouse barrel cortex slice with thalamocortical stimulation.",
  "effect_size": "5-fold larger TC inputs onto firing inhibitory interneurons; 60% vs <5% spike probability for inhibitory vs excitatory cells",
  "text_access": "abstract_only",
  "study_system": "mouse barrel cortex slice, layers IV–V",
  "source_cluster_id": "cluster_05",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Thalamocortical stimulation evoked action potentials in approximately 60% of inhibitory interneurons but in <5% of excitatory neurons.",
  "replication_evidence_dois": [
    "10.1152/jn.00549.2001",
    "10.1093/cercor/4.6.646"
  ],
  "effect_size_source_sentence": "The inhibitory interneurons that fired received fivefold larger thalamocortical inputs compared with nonfiring inhibitory or excitatory neurons."
}

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