Version history

{
  "scope": "mouse V1; long-range Cg→V1 glutamatergic projection; in vivo + behavior",
  "claim_text": "In awake mouse cortex, long-range glutamatergic projections from the cingulate (Cg/ACA) region to V1 produce a center–surround modulatory pattern: optogenetic Cg-axon activation enhances V1 responses at the activation focus but suppresses responses at nearby V1 locations, and Cg activation improves behavioral visual discrimination.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1126/science.1254126",
    "claim": "In awake mouse cortex, long-range glutamatergic projections from the cingulate (Cg/ACA) region to V1 produce a center–surround modulatory pattern: optogenetic Cg-axon activation enhances V1 responses at the activation focus but suppresses responses at nearby V1 locations, and Cg activation improves behavioral visual discrimination.",
    "cite_key": "Zhang2014",
    "evidence": "In vivo single-unit recording in V1 combined with optogenetic activation of cingulate (Cg) neurons and of their long-range axons in V1; viral GABA-circuit manipulations; behavioral visual discrimination performance under Cg activation.",
    "effect_size": "Cg activation increases V1 response at focus and decreases response at neighboring V1 sites; behavioral discrimination improved",
    "text_access": "fulltext",
    "study_system": "mouse V1; long-range Cg→V1 glutamatergic projection; in vivo + behavior",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Focal activation of Cg axons in V1 caused a response increase at the activation site but decrease at nearby locations (center-surround modulation).",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/nn.4061",
      "10.1016/j.neuron.2025.10.037"
    ],
    "effect_size_source_sentence": "Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Cg activation increases V1 response at focus and decreases response at neighboring V1 sites; behavioral discrimination improved",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-05bd6c97da43"
  ],
  "source_span": "Focal activation of Cg axons in V1 caused a response increase at the activation site but decrease at nearby locations (center-surround modulation).",
  "study_system": "mouse V1; long-range Cg→V1 glutamatergic projection; in vivo + behavior",
  "evidence_refs": [
    {
      "ref": "paper:paper-05bd6c97da43"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In vivo single-unit recording in V1 combined with optogenetic activation of cingulate (Cg) neurons and of their long-range axons in V1; viral GABA-circuit manipulations; behavioral visual discrimination performance under Cg activation.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}