Version history

{
  "scope": "human MEG (n=12) + cortical layer-2/3 computational model",
  "claim_text": "In a layer-2/3 cortical model, reducing NMDA-R activity selectively on PV or SST (but not VIP) interneurons reproduces ketamine-like increases in gamma-band power; complementary MEG analysis (n=12) showed flatter aperiodic slope and increased gamma correlated with regional PV and GRIN2D expression.",
  "raw_fields": {
    "n": 12,
    "doi": "10.1371/journal.pcbi.1013118",
    "pmid": "40489551",
    "year": "2025",
    "claim": "In a layer-2/3 cortical model, reducing NMDA-R activity selectively on PV or SST (but not VIP) interneurons reproduces ketamine-like increases in gamma-band power; complementary MEG analysis (n=12) showed flatter aperiodic slope and increased gamma correlated with regional PV and GRIN2D expression.",
    "pmcid": "PMC12204622",
    "title": "Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons.",
    "authors": "",
    "journal": "",
    "cite_key": "Rademacher2025",
    "evidence": "MEG resting-state n=12 + neural-mass cortical model with PV/SST/VIP cell-type NMDA-R manipulations.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "MEG n=12; gamma-band 30-90 Hz; flatter aperiodic slope after ketamine",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "human MEG (n=12) + cortical layer-2/3 computational model",
    "cited_by_count": 2,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 13,
    "claim_source_sentence": "Computational modeling revealed that reduced NMDA-R activity in parvalbumin or somatostatin interneurons could reproduce increased gamma-band power by increasing pyramidal neuron firing rate, but did not account for changes in the aperiodic slope.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We analyzed resting-state MEG data from n = 12 participants who were administered Ketamine to assess changes in gamma-band (30-90 Hz) power and the slope of the aperiodic power spectrum compared to placebo."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "MEG n=12; gamma-band 30-90 Hz; flatter aperiodic slope after ketamine",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-1f9e2fd192d2"
  ],
  "source_span": "Computational modeling revealed that reduced NMDA-R activity in parvalbumin or somatostatin interneurons could reproduce increased gamma-band power by increasing pyramidal neuron firing rate, but did not account for changes in the aperiodic slope.",
  "study_system": "human MEG (n=12) + cortical layer-2/3 computational model",
  "evidence_refs": [
    {
      "ref": "paper:paper-1f9e2fd192d2"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "MEG resting-state n=12 + neural-mass cortical model with PV/SST/VIP cell-type NMDA-R manipulations.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}