In a layer-2/3 cortical model, reducing NMDA-R activity selectively on PV or SS…

In a layer-2/3 cortical model, reducing NMDA-R activity selectively on PV or SST (but not VIP) interneurons reproduces ketamine-like increases in gamma-band power; complementary MEG analysis (n=12) showed flatter aperiodic slope and increased gamma correlated with regional PV and GRIN2D expression.

{
  "n": 12,
  "doi": "10.1371/journal.pcbi.1013118",
  "pmid": "40489551",
  "year": "2025",
  "claim": "In a layer-2/3 cortical model, reducing NMDA-R activity selectively on PV or SST (but not VIP) interneurons reproduces ketamine-like increases in gamma-band power; complementary MEG analysis (n=12) showed flatter aperiodic slope and increased gamma correlated with regional PV and GRIN2D expression.",
  "pmcid": "PMC12204622",
  "title": "Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons.",
  "authors": "",
  "journal": "",
  "cite_key": "Rademacher2025",
  "evidence": "MEG resting-state n=12 + neural-mass cortical model with PV/SST/VIP cell-type NMDA-R manipulations.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "MEG n=12; gamma-band 30-90 Hz; flatter aperiodic slope after ketamine",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "human MEG (n=12) + cortical layer-2/3 computational model",
  "cited_by_count": 2,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 13,
  "claim_source_sentence": "Computational modeling revealed that reduced NMDA-R activity in parvalbumin or somatostatin interneurons could reproduce increased gamma-band power by increasing pyramidal neuron firing rate, but did not account for changes in the aperiodic slope.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We analyzed resting-state MEG data from n = 12 participants who were administered Ketamine to assess changes in gamma-band (30-90 Hz) power and the slope of the aperiodic power spectrum compared to placebo."
}

[
  "paper:paper-1f9e2fd192d2"
]

Computational modeling revealed that reduced NMDA-R activity in parvalbumin or somatostatin interneurons could reproduce increased gamma-band power by increasing pyramidal neuron firing rate, but did not account for changes in the aperiodic slope.

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  }
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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