Version history

{
  "scope": "mouse ALM, optogenetic sCRACM",
  "claim_text": "VM thalamic axons excite L5B pyramidal-tract neurons of mouse ALM via inputs concentrated on apical-tuft dendrites in L1, and also strongly excite L2/3 neurons (which themselves drive PT cells), forming a translaminar excitatory thalamo-cortico-thalamic loop.",
  "raw_fields": {
    "n": "ALM slices, female and male mice; sample size not in abstract",
    "doi": "10.1523/jneurosci.1333-18.2018",
    "claim": "VM thalamic axons excite L5B pyramidal-tract neurons of mouse ALM via inputs concentrated on apical-tuft dendrites in L1, and also strongly excite L2/3 neurons (which themselves drive PT cells), forming a translaminar excitatory thalamo-cortico-thalamic loop.",
    "cite_key": "Guo2018",
    "evidence": "Optogenetic stimulation of VM thalamic axons in ALM slices with subcellular ChR2-assisted circuit mapping in retrogradely labelled VM-projecting PT/CT neurons.",
    "effect_size": "Strongest VM→PT inputs at L1 apical tufts; augmented by HCN channel block",
    "text_access": "abstract_only",
    "study_system": "mouse ALM, optogenetic sCRACM",
    "argument_role": "supporting",
    "replication_status": "consistent with L2/3→L5 descending microcircuit and L1 apical-tuft integration",
    "claim_source_sentence": "In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM. These axons also strongly excited layer 2/3 neurons (which strongly excite PT neurons, as previously shown) but not VM-projecting corticothalamic (CT) neurons in layer 6. The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.1459-18.2018"
    ],
    "effect_size_source_sentence": "The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1. These tuft inputs were selectively augmented after blocking hyperpolarization-activated cyclic nucleotide-gated (HCN) channels."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Strongest VM→PT inputs at L1 apical tufts; augmented by HCN channel block",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:e0b74a67-34de-4660-b780-ff95451e6841"
  ],
  "source_span": "In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM. These axons also strongly excited layer 2/3 neurons (which strongly excite PT neurons, as previously shown) but not VM-projecting corticothalamic (CT) neurons in layer 6. The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1.",
  "study_system": "mouse ALM, optogenetic sCRACM",
  "evidence_refs": [
    {
      "ref": "paper:e0b74a67-34de-4660-b780-ff95451e6841"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Optogenetic stimulation of VM thalamic axons in ALM slices with subcellular ChR2-assisted circuit mapping in retrogradely labelled VM-projecting PT/CT neurons.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent with L2/3→L5 descending microcircuit and L1 apical-tuft integration",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}