VM thalamic axons excite L5B pyramidal-tract neurons of mouse ALM via inputs co…

VM thalamic axons excite L5B pyramidal-tract neurons of mouse ALM via inputs concentrated on apical-tuft dendrites in L1, and also strongly excite L2/3 neurons (which themselves drive PT cells), forming a translaminar excitatory thalamo-cortico-thalamic loop.

{
  "n": "ALM slices, female and male mice; sample size not in abstract",
  "doi": "10.1523/jneurosci.1333-18.2018",
  "claim": "VM thalamic axons excite L5B pyramidal-tract neurons of mouse ALM via inputs concentrated on apical-tuft dendrites in L1, and also strongly excite L2/3 neurons (which themselves drive PT cells), forming a translaminar excitatory thalamo-cortico-thalamic loop.",
  "cite_key": "Guo2018",
  "evidence": "Optogenetic stimulation of VM thalamic axons in ALM slices with subcellular ChR2-assisted circuit mapping in retrogradely labelled VM-projecting PT/CT neurons.",
  "effect_size": "Strongest VM→PT inputs at L1 apical tufts; augmented by HCN channel block",
  "text_access": "abstract_only",
  "study_system": "mouse ALM, optogenetic sCRACM",
  "argument_role": "supporting",
  "replication_status": "consistent with L2/3→L5 descending microcircuit and L1 apical-tuft integration",
  "claim_source_sentence": "In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM. These axons also strongly excited layer 2/3 neurons (which strongly excite PT neurons, as previously shown) but not VM-projecting corticothalamic (CT) neurons in layer 6. The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1523/JNEUROSCI.1459-18.2018"
  ],
  "effect_size_source_sentence": "The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1. These tuft inputs were selectively augmented after blocking hyperpolarization-activated cyclic nucleotide-gated (HCN) channels."
}

[
  "paper:e0b74a67-34de-4660-b780-ff95451e6841"
]

In cortex, thalamocortical (TC) axons from VM thalamus excited VM-projecting pyramidal tract (PT) neurons in layer 5B of ALM. These axons also strongly excited layer 2/3 neurons (which strongly excite PT neurons, as previously shown) but not VM-projecting corticothalamic (CT) neurons in layer 6. The strongest connections in the VM → PT circuit were localized to apical tuft dendrites of PT neurons, in layer 1.

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