Version history

{
  "scope": "mouse V1 cortico-cortical projection neurons to higher visual areas; multiplexed retrograde/anterograde tracing + MAPseq",
  "claim_text": "Postnatal development of mouse V1→higher-visual-area projections follows a directed-guidance schedule, in which individual V1 cortico-cortical neurons retain specific projection motifs from the outset rather than first making global exuberant connections and pruning.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1101/2025.11.03.686379",
    "claim": "Postnatal development of mouse V1→higher-visual-area projections follows a directed-guidance schedule, in which individual V1 cortico-cortical neurons retain specific projection motifs from the outset rather than first making global exuberant connections and pruning.",
    "cite_key": "Jacobs2025",
    "evidence": "Combined retrograde and anterograde tracing plus single-cell MAPseq of V1 projection neurons to 11 higher visual areas across postnatal development in mice.",
    "effect_size": "Bidirectional V1↔HVA like-to-like connectivity refines across development",
    "text_access": "abstract_only",
    "study_system": "mouse V1 cortico-cortical projection neurons to higher visual areas; multiplexed retrograde/anterograde tracing + MAPseq",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Notably, both multiplexed retrograde tracing and MAPseq-based single-cell profiling revealed that individual V1 neurons initialize and retain specific projection motifs with limited variation over development, arguing against global exuberance followed by selective, inter-areal pruning.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Bidirectional like-to-like V1-HVA connectivity refines across development."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Bidirectional V1↔HVA like-to-like connectivity refines across development",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-774b89d25273"
  ],
  "source_span": "Notably, both multiplexed retrograde tracing and MAPseq-based single-cell profiling revealed that individual V1 neurons initialize and retain specific projection motifs with limited variation over development, arguing against global exuberance followed by selective, inter-areal pruning.",
  "study_system": "mouse V1 cortico-cortical projection neurons to higher visual areas; multiplexed retrograde/anterograde tracing + MAPseq",
  "evidence_refs": [
    {
      "ref": "paper:paper-774b89d25273"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Combined retrograde and anterograde tracing plus single-cell MAPseq of V1 projection neurons to 11 higher visual areas across postnatal development in mice.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}