Postnatal development of mouse V1→higher-visual-area projections follows a dire…

Postnatal development of mouse V1→higher-visual-area projections follows a directed-guidance schedule, in which individual V1 cortico-cortical neurons retain specific projection motifs from the outset rather than first making global exuberant connections and pruning.

{
  "n": 0,
  "doi": "10.1101/2025.11.03.686379",
  "claim": "Postnatal development of mouse V1→higher-visual-area projections follows a directed-guidance schedule, in which individual V1 cortico-cortical neurons retain specific projection motifs from the outset rather than first making global exuberant connections and pruning.",
  "cite_key": "Jacobs2025",
  "evidence": "Combined retrograde and anterograde tracing plus single-cell MAPseq of V1 projection neurons to 11 higher visual areas across postnatal development in mice.",
  "effect_size": "Bidirectional V1↔HVA like-to-like connectivity refines across development",
  "text_access": "abstract_only",
  "study_system": "mouse V1 cortico-cortical projection neurons to higher visual areas; multiplexed retrograde/anterograde tracing + MAPseq",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Notably, both multiplexed retrograde tracing and MAPseq-based single-cell profiling revealed that individual V1 neurons initialize and retain specific projection motifs with limited variation over development, arguing against global exuberance followed by selective, inter-areal pruning.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Bidirectional like-to-like V1-HVA connectivity refines across development."
}

[
  "paper:paper-774b89d25273"
]

Notably, both multiplexed retrograde tracing and MAPseq-based single-cell profiling revealed that individual V1 neurons initialize and retain specific projection motifs with limited variation over development, arguing against global exuberance followed by selective, inter-areal pruning.

[
  {
    "ref": "paper:paper-774b89d25273"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}