Version history

{
  "scope": "rat neocortex PV and SST interneurons",
  "claim_text": "Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they form heteromultimeric channels with Kv3.1, while in superficial layers PV neurons express Kv3.1 but low Kv3.2, suggesting differential neuromodulatory regulation of fast-spiking properties across cortical layers.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.19-21-09332.1999",
    "claim": "Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they form heteromultimeric channels with Kv3.1, while in superficial layers PV neurons express Kv3.1 but low Kv3.2, suggesting differential neuromodulatory regulation of fast-spiking properties across cortical layers.",
    "evidence": "Immunohistochemical dual-labeling in neocortex showed Kv3.2 prominently in somatic and dendritic membranes as well as axons and terminals of GABAergic interneurons, with layer-specific expression differences.",
    "effect_size": "Kv3.2 in all deep-layer PV neurons but low in superficial PV neurons; Kv3.2 also in somatostatin/calbindin-containing non-FS interneurons",
    "text_access": "abstract_only",
    "study_system": "rat neocortex PV and SST interneurons",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they probably form heteromultimeric channels with Kv3.1 subunits. In contrast, in superficial layer PV-positive neurons Kv3.2 immunoreactivity is low, but Kv3.1 is still prominently expressed.",
    "replication_evidence_dois": [
      "10.1152/physrev.00002.2017"
    ],
    "effect_size_source_sentence": "Kv3.2 but not Kv3.1 proteins are also prominent in a subset of seemingly non-fast-spiking, somatostatin- and calbindin-containing interneurons, suggesting that the Kv3.1-Kv3.2 current type can have functions other than facilitating high-frequency firing."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "Kv3.2 in all deep-layer PV neurons but low in superficial PV neurons; Kv3.2 also in somatostatin/calbindin-containing non-FS interneurons",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-be884a23ba97"
  ],
  "source_span": "Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they probably form heteromultimeric channels with Kv3.1 subunits. In contrast, in superficial layer PV-positive neurons Kv3.2 immunoreactivity is low, but Kv3.1 is still prominently expressed.",
  "study_system": "rat neocortex PV and SST interneurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-be884a23ba97"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Immunohistochemical dual-labeling in neocortex showed Kv3.2 prominently in somatic and dendritic membranes as well as axons and terminals of GABAergic interneurons, with layer-specific expression differences.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}