- claim_text
Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they form heteromultimeric channels with Kv3.1, while in superficial layers PV neurons express Kv3.1 but low Kv3.2, suggesting differential neuromodulatory regulation of fast-spiking properties across cortical layers.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.19-21-09332.1999",
"claim": "Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they form heteromultimeric channels with Kv3.1, while in superficial layers PV neurons express Kv3.1 but low Kv3.2, suggesting differential neuromodulatory regulation of fast-spiking properties across cortical layers.",
"evidence": "Immunohistochemical dual-labeling in neocortex showed Kv3.2 prominently in somatic and dendritic membranes as well as axons and terminals of GABAergic interneurons, with layer-specific expression differences.",
"effect_size": "Kv3.2 in all deep-layer PV neurons but low in superficial PV neurons; Kv3.2 also in somatostatin/calbindin-containing non-FS interneurons",
"text_access": "abstract_only",
"study_system": "rat neocortex PV and SST interneurons",
"replication_status": "independently_replicated",
"claim_source_sentence": "Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they probably form heteromultimeric channels with Kv3.1 subunits. In contrast, in superficial layer PV-positive neurons Kv3.2 immunoreactivity is low, but Kv3.1 is still prominently expressed.",
"replication_evidence_dois": [
"10.1152/physrev.00002.2017"
],
"effect_size_source_sentence": "Kv3.2 but not Kv3.1 proteins are also prominent in a subset of seemingly non-fast-spiking, somatostatin- and calbindin-containing interneurons, suggesting that the Kv3.1-Kv3.2 current type can have functions other than facilitating high-frequency firing."
}- source_refs
[
"paper:paper-be884a23ba97"
]
- source_span
Kv3.2 subunits are found in all PV-containing neurons in deep cortical layers where they probably form heteromultimeric channels with Kv3.1 subunits. In contrast, in superficial layer PV-positive neurons Kv3.2 immunoreactivity is low, but Kv3.1 is still prominently expressed.
- evidence_refs
[
{
"ref": "paper:paper-be884a23ba97"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}