Version history

{
  "scope": "mouse thalamocortical slice preparation",
  "claim_text": "Thalamocortical axons drive robust synaptic responses in cortical FS interneurons and excitatory cells but only weak responses in SOM interneurons; strong FS activation leads to feedforward inhibition in all cortical neuron types",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2009.12.025",
    "claim": "Thalamocortical axons drive robust synaptic responses in cortical FS interneurons and excitatory cells but only weak responses in SOM interneurons; strong FS activation leads to feedforward inhibition in all cortical neuron types",
    "evidence": "Optogenetic activation of ChR2-expressing thalamocortical vs corticothalamic pathways with paired recordings",
    "effect_size": "FS cells received strong TC input; SOM cells received weak TC input",
    "text_access": "fulltext",
    "study_system": "mouse thalamocortical slice preparation",
    "replication_status": "independently replicated",
    "claim_source_sentence": "Laser stimulation of ChR2-expressing thalamocortical axons/terminals evoked robust synaptic responses in cortical excitatory cells and fast-spiking (FS) inhibitory interneurons, but only weak responses in somatostatin-containing interneurons. Strong FS cell activation led to feedforward inhibition in all cortical neuron types, including FS cells.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.4727-04.2006",
      "10.1523/JNEUROSCI.4565-14.2015"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "FS cells received strong TC input; SOM cells received weak TC input",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-046e316a15e6"
  ],
  "source_span": "Laser stimulation of ChR2-expressing thalamocortical axons/terminals evoked robust synaptic responses in cortical excitatory cells and fast-spiking (FS) inhibitory interneurons, but only weak responses in somatostatin-containing interneurons. Strong FS cell activation led to feedforward inhibition in all cortical neuron types, including FS cells.",
  "study_system": "mouse thalamocortical slice preparation",
  "evidence_refs": [
    {
      "ref": "paper:paper-046e316a15e6"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Optogenetic activation of ChR2-expressing thalamocortical vs corticothalamic pathways with paired recordings",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}