Version history

{
  "scope": "mouse (auditory cortex, CS-L4 viral tracing + slice optogenetics)",
  "claim_text": "Mouse auditory cortex contains a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) that receives direct thalamic inputs and projects to the posterior dorsal striatum.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.1738-21.2021",
    "claim": "Mouse auditory cortex contains a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) that receives direct thalamic inputs and projects to the posterior dorsal striatum.",
    "cite_key": "Bertero2022",
    "evidence": "Anatomic, electrophysiological, and optogenetic characterization of layer 4 corticostriatal pyramidal neurons in mouse auditory cortex projecting to posterior striatum.",
    "effect_size": "qualitative — establishes new CS-L4 cell type and feedforward inhibitory thalamo→cortico(L4)→striatal circuit",
    "text_access": "abstract_only",
    "study_system": "mouse (auditory cortex, CS-L4 viral tracing + slice optogenetics)",
    "source_cluster_id": "cluster_03",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Here, taking advantage of anatomic, electrophysiological, and optogenetic techniques, we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "The CS-L4 neurons are embedded in a feedforward inhibitory circuit involving local parvalbumin neurons and establish connections in the posterior striatum in yet another feedforward inhibitory thalamo→cortico(L4)→striatal circuit which potentially contributes in controlling control the output of striatal spiny projection neurons."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "effect_size": "qualitative — establishes new CS-L4 cell type and feedforward inhibitory thalamo→cortico(L4)→striatal circuit",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-a5667e433556"
  ],
  "source_span": "Here, taking advantage of anatomic, electrophysiological, and optogenetic techniques, we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs.",
  "study_system": "mouse (auditory cortex, CS-L4 viral tracing + slice optogenetics)",
  "evidence_refs": [
    {
      "ref": "paper:paper-a5667e433556"
    }
  ],
  "section_title": "The Cortico-Striatal Interface: Topography, Cell Types, and Input Convergence",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Anatomic, electrophysiological, and optogenetic characterization of layer 4 corticostriatal pyramidal neurons in mouse auditory cortex projecting to posterior striatum.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}