Mouse auditory cortex contains a long-range corticostriatal class of pyramidal…

{
  "n": null,
  "doi": "10.1523/jneurosci.1738-21.2021",
  "claim": "Mouse auditory cortex contains a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) that receives direct thalamic inputs and projects to the posterior dorsal striatum.",
  "cite_key": "Bertero2022",
  "evidence": "Anatomic, electrophysiological, and optogenetic characterization of layer 4 corticostriatal pyramidal neurons in mouse auditory cortex projecting to posterior striatum.",
  "effect_size": "qualitative — establishes new CS-L4 cell type and feedforward inhibitory thalamo→cortico(L4)→striatal circuit",
  "text_access": "abstract_only",
  "study_system": "mouse (auditory cortex, CS-L4 viral tracing + slice optogenetics)",
  "source_cluster_id": "cluster_03",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Here, taking advantage of anatomic, electrophysiological, and optogenetic techniques, we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "The CS-L4 neurons are embedded in a feedforward inhibitory circuit involving local parvalbumin neurons and establish connections in the posterior striatum in yet another feedforward inhibitory thalamo→cortico(L4)→striatal circuit which potentially contributes in controlling control the output of striatal spiny projection neurons."
}

[
  "paper:paper-a5667e433556"
]

Here, taking advantage of anatomic, electrophysiological, and optogenetic techniques, we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs.

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