Version history

{
  "scope": "Mouse somatosensory cortex; retrograde tracing from L1 and acute-slice optogenetics of intratelencephalic L5 pyramidal neurons",
  "claim_text": "In mouse somatosensory cortex, layer 1 receives local input predominantly from L2/3 and L5 pyramidal neurons and interneurons, while long-range sensory-motor cortical input to L1 of S1 arises mainly from L2/3 neurons; intratelencephalic L5 pyramids drive L1 interneurons but do not directly excite local L5 apical tufts.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1093/cercor/bhad371",
    "claim": "In mouse somatosensory cortex, layer 1 receives local input predominantly from L2/3 and L5 pyramidal neurons and interneurons, while long-range sensory-motor cortical input to L1 of S1 arises mainly from L2/3 neurons; intratelencephalic L5 pyramids drive L1 interneurons but do not directly excite local L5 apical tufts.",
    "cite_key": "Ledderose2023",
    "evidence": "Retrograde tracing and optogenetic circuit mapping of local and long-range inputs to L1 of mouse S1 in vivo and in slice.",
    "effect_size": "L5 IT → L1 interneurons: clear excitation; L5 IT → local L5 apical tufts: no significant effect.",
    "text_access": "fulltext",
    "study_system": "Mouse somatosensory cortex; retrograde tracing from L1 and acute-slice optogenetics of intratelencephalic L5 pyramidal neurons",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Our assays reveal that local input to layer 1 is predominantly from layers 2/3 and 5 pyramidal neurons and interneurons, and that subtypes of local layers 5 and 6b neurons project to layer 1 with different probabilities. Long-range input from sensory-motor cortices to layer 1 of somatosensory cortex arose predominantly from layers 2/3 neurons. Our optogenetic experiments showed that intra-telencephalic layer 5 pyramidal neurons drive layer 1 interneurons but have no effect locally on layer 5 apical tuft dendrites.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "intra-telencephalic layer 5 pyramidal neurons drive layer 1 interneurons but have no effect locally on layer 5 apical tuft dendrites"
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L5 IT → L1 interneurons: clear excitation; L5 IT → local L5 apical tufts: no significant effect.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-189d92c83cf0"
  ],
  "source_span": "Our assays reveal that local input to layer 1 is predominantly from layers 2/3 and 5 pyramidal neurons and interneurons, and that subtypes of local layers 5 and 6b neurons project to layer 1 with different probabilities. Long-range input from sensory-motor cortices to layer 1 of somatosensory cortex arose predominantly from layers 2/3 neurons. Our optogenetic experiments showed that intra-telencephalic layer 5 pyram...",
  "study_system": "Mouse somatosensory cortex; retrograde tracing from L1 and acute-slice optogenetics of intratelencephalic L5 pyramidal neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-189d92c83cf0"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Retrograde tracing and optogenetic circuit mapping of local and long-range inputs to L1 of mouse S1 in vivo and in slice.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}