In mouse somatosensory cortex, layer 1 receives local input predominantly from…

In mouse somatosensory cortex, layer 1 receives local input predominantly from L2/3 and L5 pyramidal neurons and interneurons, while long-range sensory-motor cortical input to L1 of S1 arises mainly from L2/3 neurons; intratelencephalic L5 pyramids drive L1 interneurons but do not directly excite local L5 apical tufts.

{
  "n": 0,
  "doi": "10.1093/cercor/bhad371",
  "claim": "In mouse somatosensory cortex, layer 1 receives local input predominantly from L2/3 and L5 pyramidal neurons and interneurons, while long-range sensory-motor cortical input to L1 of S1 arises mainly from L2/3 neurons; intratelencephalic L5 pyramids drive L1 interneurons but do not directly excite local L5 apical tufts.",
  "cite_key": "Ledderose2023",
  "evidence": "Retrograde tracing and optogenetic circuit mapping of local and long-range inputs to L1 of mouse S1 in vivo and in slice.",
  "effect_size": "L5 IT → L1 interneurons: clear excitation; L5 IT → local L5 apical tufts: no significant effect.",
  "text_access": "fulltext",
  "study_system": "Mouse somatosensory cortex; retrograde tracing from L1 and acute-slice optogenetics of intratelencephalic L5 pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Our assays reveal that local input to layer 1 is predominantly from layers 2/3 and 5 pyramidal neurons and interneurons, and that subtypes of local layers 5 and 6b neurons project to layer 1 with different probabilities. Long-range input from sensory-motor cortices to layer 1 of somatosensory cortex arose predominantly from layers 2/3 neurons. Our optogenetic experiments showed that intra-telencephalic layer 5 pyramidal neurons drive layer 1 interneurons but have no effect locally on layer 5 apical tuft dendrites.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "intra-telencephalic layer 5 pyramidal neurons drive layer 1 interneurons but have no effect locally on layer 5 apical tuft dendrites"
}

[
  "paper:paper-189d92c83cf0"
]

Our assays reveal that local input to layer 1 is predominantly from layers 2/3 and 5 pyramidal neurons and interneurons, and that subtypes of local layers 5 and 6b neurons project to layer 1 with different probabilities. Long-range input from sensory-motor cortices to layer 1 of somatosensory cortex arose predominantly from layers 2/3 neurons. Our optogenetic experiments showed that intra-telencephalic layer 5 pyram...

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