Beyond 15 years after bilateral STN-DBS, time spent with dyskinesia is reduced…

{
  "n": 51,
  "doi": "10.1212/wnl.0000000000012246",
  "claim": "Beyond 15 years after bilateral STN-DBS, time spent with dyskinesia is reduced by 75% and time in OFF by 58.7%, with a 50.6% reduction in dopaminergic medication.",
  "cite_key": "Bove2021",
  "evidence": "Retrospective cohort of 51 PD patients with mean 17.06 ± 2.18 years of STN-DBS follow-up; pre-op, 1-year, and 15+-year comparisons.",
  "effect_size": "Dyskinesia time -75%; OFF time -58.7%; dopaminergic drugs -50.6%",
  "text_access": "abstract_only",
  "study_system": "Long-term PD STN-DBS cohort (n=51, 15+ years follow-up)",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Compared to baseline, the time spent with dyskinesia and the time spent in the \"off\" state were reduced by 75% (p < 0.001) and by 58.7% (p < 0.001), respectively. Moreover, dopaminergic drugs were reduced by 50.6% (p < 0.001).",
  "replication_evidence_dois": [
    "10.21203/rs.3.rs-8860454/v1",
    "10.21203/rs.3.rs-9205154/v1"
  ],
  "effect_size_source_sentence": "Compared to baseline, the time spent with dyskinesia and the time spent in the \"off\" state were reduced by 75% (p < 0.001) and by 58.7% (p < 0.001), respectively. Moreover, dopaminergic drugs were reduced by 50.6% (p < 0.001)."
}

[
  "paper:paper-ed387411989d"
]

[
  {
    "ref": "paper:paper-ed387411989d"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}