Version history

{
  "scope": "Long-term PD STN-DBS cohort (n=51, 15+ years follow-up)",
  "claim_text": "Beyond 15 years after bilateral STN-DBS, time spent with dyskinesia is reduced by 75% and time in OFF by 58.7%, with a 50.6% reduction in dopaminergic medication.",
  "raw_fields": {
    "n": 51,
    "doi": "10.1212/wnl.0000000000012246",
    "claim": "Beyond 15 years after bilateral STN-DBS, time spent with dyskinesia is reduced by 75% and time in OFF by 58.7%, with a 50.6% reduction in dopaminergic medication.",
    "cite_key": "Bove2021",
    "evidence": "Retrospective cohort of 51 PD patients with mean 17.06 ± 2.18 years of STN-DBS follow-up; pre-op, 1-year, and 15+-year comparisons.",
    "effect_size": "Dyskinesia time -75%; OFF time -58.7%; dopaminergic drugs -50.6%",
    "text_access": "abstract_only",
    "study_system": "Long-term PD STN-DBS cohort (n=51, 15+ years follow-up)",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Compared to baseline, the time spent with dyskinesia and the time spent in the \"off\" state were reduced by 75% (p < 0.001) and by 58.7% (p < 0.001), respectively. Moreover, dopaminergic drugs were reduced by 50.6% (p < 0.001).",
    "replication_evidence_dois": [
      "10.21203/rs.3.rs-8860454/v1",
      "10.21203/rs.3.rs-9205154/v1"
    ],
    "effect_size_source_sentence": "Compared to baseline, the time spent with dyskinesia and the time spent in the \"off\" state were reduced by 75% (p < 0.001) and by 58.7% (p < 0.001), respectively. Moreover, dopaminergic drugs were reduced by 50.6% (p < 0.001)."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": "Dyskinesia time -75%; OFF time -58.7%; dopaminergic drugs -50.6%",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-ed387411989d"
  ],
  "source_span": "Compared to baseline, the time spent with dyskinesia and the time spent in the \"off\" state were reduced by 75% (p < 0.001) and by 58.7% (p < 0.001), respectively. Moreover, dopaminergic drugs were reduced by 50.6% (p < 0.001).",
  "study_system": "Long-term PD STN-DBS cohort (n=51, 15+ years follow-up)",
  "evidence_refs": [
    {
      "ref": "paper:paper-ed387411989d"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Retrospective cohort of 51 PD patients with mean 17.06 ± 2.18 years of STN-DBS follow-up; pre-op, 1-year, and 15+-year comparisons.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}