Version history

{
  "scope": "mouse VISp; patch-seq",
  "claim_text": "Multimodal patch-seq integration of >4,200 mouse VISp GABAergic interneurons defines 28 morpho-electric-transcriptomic (MET) types whose layer-specific axon innervation patterns are the principal feature distinguishing them, providing a unified VIP/SST/PV/LAMP5/SNCG taxonomy in which transcriptomic identity, intrinsic electrophysiology, and morphology are mutually predictable.",
  "raw_fields": {
    "n": 4270,
    "doi": "10.1016/j.cell.2020.09.057",
    "claim": "Multimodal patch-seq integration of >4,200 mouse VISp GABAergic interneurons defines 28 morpho-electric-transcriptomic (MET) types whose layer-specific axon innervation patterns are the principal feature distinguishing them, providing a unified VIP/SST/PV/LAMP5/SNCG taxonomy in which transcriptomic identity, intrinsic electrophysiology, and morphology are mutually predictable.",
    "title": null,
    "cite_key": "Gouwens2020a",
    "evidence": "patch-seq characterization of 4,270 mouse VISp interneurons (transcriptome+ephys); 517 reconstructed morphologies (Gouwens et al 2020 Cell)",
    "effect_size": "28 MET-types; ~78% met-type prediction accuracy from ephys+morph",
    "text_access": "fulltext",
    "study_system": "mouse VISp; patch-seq",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 62,
    "claim_source_sentence": "Through multimodal integrated analysis we define 28 met-types that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability.",
    "replication_evidence_dois": [
      "10.1038/s41586-020-2907-3",
      "10.1038/s41586-018-0654-5"
    ],
    "effect_size_source_sentence": "Prediction of met-types using combined electrophysiological and morphological features did have a higher accuracy (~78%) than t-type prediction."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "28 MET-types; ~78% met-type prediction accuracy from ephys+morph",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-33186530"
  ],
  "source_span": "Through multimodal integrated analysis we define 28 met-types that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability.",
  "study_system": "mouse VISp; patch-seq",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-33186530"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "patch-seq characterization of 4,270 mouse VISp interneurons (transcriptome+ephys); 517 reconstructed morphologies (Gouwens et al 2020 Cell)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}