Details
- scope
- mouse VISp; patch-seq
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- effect_size
- 28 MET-types; ~78% met-type prediction accuracy from ephys+morph
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- Through multimodal integrated analysis we define 28 met-types that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability.
- study_system
- mouse VISp; patch-seq
- section_title
- Intrinsic Electrophysiology
- evidence_summary
- patch-seq characterization of 4,270 mouse VISp interneurons (transcriptome+ephys); 517 reconstructed morphologies (Gouwens et al 2020 Cell)
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Multimodal patch-seq integration of >4,200 mouse VISp GABAergic interneurons defines 28 morpho-electric-transcriptomic (MET) types whose layer-specific axon innervation patterns are the principal feature distinguishing them, providing a unified VIP/SST/PV/LAMP5/SNCG taxonomy in which transcriptomic identity, intrinsic electrophysiology, and morphology are mutually predictable.
- raw_fields
{ "n": 4270, "doi": "10.1016/j.cell.2020.09.057", "claim": "Multimodal patch-seq integration of >4,200 mouse VISp GABAergic interneurons defines 28 morpho-electric-transcriptomic (MET) types whose layer-specific axon innervation patterns are the principal feature distinguishing them, providing a unified VIP/SST/PV/LAMP5/SNCG taxonomy in which transcriptomic identity, intrinsic electrophysiology, and morphology are mutually predictable.", "title": null, "cite_key": "Gouwens2020a", "evidence": "patch-seq characterization of 4,270 mouse VISp interneurons (transcriptome+ephys); 517 reconstructed morphologies (Gouwens et al 2020 Cell)", "effect_size": "28 MET-types; ~78% met-type prediction accuracy from ephys+morph", "text_access": "fulltext", "study_system": "mouse VISp; patch-seq", "_source_cluster": "cluster_04_intrinsic_electrophysiology", "replication_status": "replicated", "_source_cluster_index": 62, "claim_source_sentence": "Through multimodal integrated analysis we define 28 met-types that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability.", "replication_evidence_dois": [ "10.1038/s41586-020-2907-3", "10.1038/s41586-018-0654-5" ], "effect_size_source_sentence": "Prediction of met-types using combined electrophysiological and morphological features did have a higher accuracy (~78%) than t-type prediction." }- source_refs
[ "paper:paper-pm-33186530" ]
- evidence_refs
[ { "ref": "paper:paper-pm-33186530" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }