Version history

{
  "scope": "mouse V1 L2/3 paired patch",
  "claim_text": "VIP cells contact pyramidal neurons with very low probability (~12.5%) compared to ~100% for both PV and SST cells, with the smallest unitary IPSC charge among the three classes (uIPSQ_VIP = 0.47±0.12 pC vs. PV 2.8±0.64 pC vs. SST 1.51±0.3 pC) — meaning the *direct* VIP→pyramid inhibitory contribution is 25–50× smaller than PV or SST contributions, and the VIP class operates almost exclusively via SST disinhibition.",
  "raw_fields": {
    "n": 4,
    "doi": "10.1038/nn.3446",
    "claim": "VIP cells contact pyramidal neurons with very low probability (~12.5%) compared to ~100% for both PV and SST cells, with the smallest unitary IPSC charge among the three classes (uIPSQ_VIP = 0.47±0.12 pC vs. PV 2.8±0.64 pC vs. SST 1.51±0.3 pC) — meaning the *direct* VIP→pyramid inhibitory contribution is 25–50× smaller than PV or SST contributions, and the VIP class operates almost exclusively via SST disinhibition.",
    "title": null,
    "cite_key": "Pfeffer2013",
    "evidence": "paired patch (Pfeffer 2013)",
    "effect_size": "P_con(VIP→Pyr) ≈ 12.5%; uIPSQ ratio Pvalb:Sst:VIP = 1:0.54:0.02",
    "text_access": "fulltext",
    "study_system": "mouse V1 L2/3 paired patch",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 83,
    "claim_source_sentence": "VIP cells contacted pyramids with only ~12.5% probability.",
    "replication_evidence_dois": [
      "10.1038/ncomms13664"
    ],
    "effect_size_source_sentence": "The INC for Pvalb, Sst, and VIP cells onto pyramids was 2.8pC, 1.5pC, and 0.06pC, respectively, and can be given as the normalized ratio Pvalb:Sst:VIP=1:0.54:0.02."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "P_con(VIP→Pyr) ≈ 12.5%; uIPSQ ratio Pvalb:Sst:VIP = 1:0.54:0.02",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-1659c2dc5d60"
  ],
  "source_span": "VIP cells contacted pyramids with only ~12.5% probability.",
  "study_system": "mouse V1 L2/3 paired patch",
  "evidence_refs": [
    {
      "ref": "paper:paper-1659c2dc5d60"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "paired patch (Pfeffer 2013)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}