VIP cells contact pyramidal neurons with very low probability (~12.5%) compared…

Details

scope: mouse V1 L2/3 paired patch
section_id: section_05
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
effect_size: P_con(VIP→Pyr) ≈ 12.5%; uIPSQ ratio Pvalb:Sst:VIP = 1:0.54:0.02
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-05-electrophysiology
source_kind: review_finding
source_path: evidence/section_05_evidence_package.json
source_span: VIP cells contacted pyramids with only ~12.5% probability.
study_system: mouse V1 L2/3 paired patch
section_title: Intrinsic Electrophysiology
evidence_summary: paired patch (Pfeffer 2013)
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: replicated
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-05-electrophysiology
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (5)

claim_text

VIP cells contact pyramidal neurons with very low probability (~12.5%) compared to ~100% for both PV and SST cells, with the smallest unitary IPSC charge among the three classes (uIPSQ_VIP = 0.47±0.12 pC vs. PV 2.8±0.64 pC vs. SST 1.51±0.3 pC) — meaning the *direct* VIP→pyramid inhibitory contribution is 25–50× smaller than PV or SST contributions, and the VIP class operates almost exclusively via SST disinhibition.

raw_fields

{
  "n": 4,
  "doi": "10.1038/nn.3446",
  "claim": "VIP cells contact pyramidal neurons with very low probability (~12.5%) compared to ~100% for both PV and SST cells, with the smallest unitary IPSC charge among the three classes (uIPSQ_VIP = 0.47±0.12 pC vs. PV 2.8±0.64 pC vs. SST 1.51±0.3 pC) — meaning the *direct* VIP→pyramid inhibitory contribution is 25–50× smaller than PV or SST contributions, and the VIP class operates almost exclusively via SST disinhibition.",
  "title": null,
  "cite_key": "Pfeffer2013",
  "evidence": "paired patch (Pfeffer 2013)",
  "effect_size": "P_con(VIP→Pyr) ≈ 12.5%; uIPSQ ratio Pvalb:Sst:VIP = 1:0.54:0.02",
  "text_access": "fulltext",
  "study_system": "mouse V1 L2/3 paired patch",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 83,
  "claim_source_sentence": "VIP cells contacted pyramids with only ~12.5% probability.",
  "replication_evidence_dois": [
    "10.1038/ncomms13664"
  ],
  "effect_size_source_sentence": "The INC for Pvalb, Sst, and VIP cells onto pyramids was 2.8pC, 1.5pC, and 0.06pC, respectively, and can be given as the normalized ratio Pvalb:Sst:VIP=1:0.54:0.02."
}

source_refs

[
  "paper:paper-1659c2dc5d60"
]

evidence_refs

[
  {
    "ref": "paper:paper-1659c2dc5d60"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

VIP cells contact pyramidal neurons with very low probability (~12.5%) compared…

Details

Replication

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