Version history

{
  "scope": "mouse visual cortex (V1 + higher visual areas); MICrONS millimetre-scale functional connectomics",
  "claim_text": "Millimetre-scale MICrONS connectomic-functional data extend the like-to-like rule beyond local L2/3 pairs: feature-tuned similarity predicts connectivity within and across cortical layers and across visual areas, including feedback projections.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41586-025-08840-3",
    "claim": "Millimetre-scale MICrONS connectomic-functional data extend the like-to-like rule beyond local L2/3 pairs: feature-tuned similarity predicts connectivity within and across cortical layers and across visual areas, including feedback projections.",
    "cite_key": "Ding2025",
    "evidence": "Co-registered two-photon functional imaging and large-volume serial-section EM of mouse visual cortex. Feature vs spatial RF components separated via a digital-twin model; only feature similarity predicted fine-scale connectivity beyond axon–dendrite proximity.",
    "effect_size": "Pairwise like-to-like preserved across layers/areas; additional higher-order rule (postsynaptic cohorts share tuning more than pairwise rule predicts)",
    "text_access": "abstract_only",
    "study_system": "mouse visual cortex (V1 + higher visual areas); MICrONS millimetre-scale functional connectomics",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-to-like' connectivity across the visual hierarchy.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/nature09880",
      "10.1038/nature14182",
      "10.1038/nature17192"
    ],
    "effect_size_source_sentence": "We also discovered a higher-order rule whereby postsynaptic neuron cohorts downstream of presynaptic cells show greater functional similarity than predicted by a pairwise like-to-like rule."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Pairwise like-to-like preserved across layers/areas; additional higher-order rule (postsynaptic cohorts share tuning more than pairwise rule predicts)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-7ac22819c082"
  ],
  "source_span": "Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-to-like' connectivity across the visual hierarchy.",
  "study_system": "mouse visual cortex (V1 + higher visual areas); MICrONS millimetre-scale functional connectomics",
  "evidence_refs": [
    {
      "ref": "paper:paper-7ac22819c082"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Co-registered two-photon functional imaging and large-volume serial-section EM of mouse visual cortex. Feature vs spatial RF components separated via a digital-twin model; only feature similarity predicted fine-scale connectivity beyond axon–dendrite proximity.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}